复方α-酮酸片治疗慢性肾功能不全胱抑素-C改变的临床研究

目的：观察复方α—酮酸片治疗慢性肾功能不全的临床效果及对胱抑素(Cys—C)改变的影响。方法：选择慢性肾功能不全患60例，简单随机分成治疗组30例及对照组30例，对照组采取低蛋白低磷饮食治疗及西医对症处理；治疗组在对照组的基础上结合复方α—酮酸片治疗；选取正常体检30例作为正常组，观察(Cys—C)、Scr、TC、HB、HDL治疗前后的变化，Cys—C采用乳胶颗粒增强比浊法测定，Scr、TH、HB、HDL采用常规方法测定。结果：治疗组和对照组治疗前后各项指标相比均有所改善，治疗组治疗后Cys—C、Scr水平明显下降(P＜0．05)。结论：复方α—酮酸片能改善患肾功能、血脂紊乱和营养状况，并为Cys-C早期诊断慢性肾功能不全提供临床理论依据。

Efficacy of ketosteril in treatment of chronic renal failure with high level of plasma Cys-C

AIM: To observe the efficacy of ketosteril in treatm en t of chronic renal failure with high level of plasma Cys-C. METHODS: 60 patients with chronic renal failure were randomly divided into treatmen t group and control group. The control group was adopted a low protein and low p hosphorum diet and correcting symptoms; the treatment group, based on the therap y of the control group, was given ketosteril; 30 healthy subjects were used as t he normal control to observe changes of Cys-C, Scr, TC, HB, and HDL before and after the treatment. RESULTS: The levels of Cys-C and Scr decre ased after the administration of ketosteril (P< 0.05 ). CONCLUSION: Ketosteril shows a better effect on decreasing the levels of Cys-C and Scr in patients with CRF.