| 葛根素在大鼠体内的药动学研究 |
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| 引用本文： | 吴恒,陈礼明,张善堂.葛根素在大鼠体内的药动学研究[J].安徽医药,2010,14(2):139-141. |
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| 作者姓名： | 吴恒 陈礼明 张善堂 |
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| 作者单位： | 安徽医科大学药学院,安徽,合肥,230032;安徽省立医院药剂科,安徽,合肥,230001;安徽省立医院药剂科,安徽,合肥,230001 |
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| 基金项目： | 安徽省2008年度科研计划项目(No08020303074) |
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| 摘 要： | 目的研究葛根素在大鼠体内的药动学。方法对大鼠灌胃给药，高效液相色谱（HPLC）法测定葛根素的血药浓度，用DAS2．1．1数据处理软件计算药动学参数。结果葛根素在0．10—10．00mg·L^-1范围内线性良好（r=0．9995）。主要药动学参数如下：t1／2α=（0．549±0．397）h，t1／2β=（9．751±4．585）h，CL/F=（32．937±12．695）L·h^-1·kg^-1，Cmax=（0．545±0．051）mg·L·-1，tmax=（0．799±0．183）h，AUC=（3．384±1．166）mg·L^-1·h^-1。结论建立了HPLC法测定葛根素血药浓度的方法，适用于葛根素的药动学研究，为合理利用葛根素提供参考。
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| 关 键 词： | 葛根素 药动学 高效液相 |
Pharmacokinetic investigation of Puerarin in Rats |
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| WU Heng,CHEN Li-ming,ZHANG Shan-tang.Pharmacokinetic investigation of Puerarin in Rats[J].Anhui Medical and Pharmaceutical Journal,2010,14(2):139-141. |
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| Authors: | WU Heng CHEN Li-ming ZHANG Shan-tang |
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| Affiliation: | 1.College of Pharmacy;Anhui Medical University;2.Anhui Provincial Hospital;Hefei 230001 |
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| Abstract: | Aim To investigate pharmacokinetics of puerarin in rats. Methods Puerarin was intragastrically given to the rats. The plasma concentration of puerarin was determined by HPLC. The data were processed by DAS 2.1.1 software to calculate the pharmacokinetic parameters. Results Chromatographic peaks for puerarin were separated well by the HPLC method. The main pharmacokinetic parameters for puerarin after oral administration were as follows：t1/2α was （0.549±0.397）h,t1/2β was （9.751±4.585）h,CL/F was （32.937±12.695）L·h^-1·kg^-1,Cmax was （0.545±0.051）mg·L·-1,tmax was （0.799±0.183）h,AUC was （3.384±1.166）mg·L^-1·h^-1. Conclusion To establish a RP-HPLC method for the determination of plasma concentration of puerarin, for application in pharmacokinetic studies. It will provide reference for puerarin reasonably use. |
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| Keywords: | puerarin pharmacokinetics HPLC |
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