胃肠道间质瘤90例诊治分析

目的 探讨胃肠道问质瘤(gastrointestinal stromal tumor,GIST)的临床及病理特点、治疗方法和预后.方法 对2003年1月至2010年12月90例经病理确诊为GIST患者的临床资料进行回顾性分析并复习文献.结果 患者最常见的临床表现为消化道出血34例(37.8%),腹痛32例(35.6...

Diagnosis and treatment for gastrointestinal stromal tumour:review of 90 cases

Aim To investigate the clinical characteristics,treatment and prognosis of gastrointestinal stromal tumors（GIST）.Methods The clinieal data from 90 patients with pathologically performed GIST who were admitted to the hospital between Jan.2003 and Dec 2010,were retrospectively analyzed.Results Most of the GIST originated from stomach（68.9%）and small intestine（20%）.The clinical signs in 82 cases（91.16%）included gastrointestinal bleeding,epigastic pain and mass in abdomen.The pathological examination showed 18（20%） were malignant lesions,26.7 percent（24/90） were high-risk,33.3 percent（30/90） were intermediate-risk,13.3 percent（12/90） were low-risk,and 6.7 percent（6/90） were very low-risk gastrointestinal stromal tumors in patients.The positive rates of CDl17 and CD34 in GIST patients were 98.9%and 77.8%respectively.In all patients with GIST,81.8%had complete resections of the tumor.89 patients（15 with metastasis and 6 being relapse）were treated with imatinib with responsive rate of 98.8%.Conclusions The diagnosis of GIST relies on histopathological and immunohistochemical examinations because of lacking specific clinical menifestaions.CD117 is an important marker for the diagnosis of GIST and radical resection of the tumor is important in treatment of GIST.Molecular target therapy of imatinib can prolong the survival time of the patients with advanced GIST.