| 穿心莲内酯及其衍生物药代动力学研究进展 |
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| 作者姓名： | 杨灵 王凯 丁丽琴 乔淼 侯文彬 邱峰 |
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| 作者单位： | 1.天津中医药大学中药学院，天津 300193；2.天津中医药大学中医药研究院，天津 300193,1.天津中医药大学中药学院，天津 300193,2.天津中医药大学中医药研究院，天津 300193,1.天津中医药大学中药学院，天津 300193；2.天津中医药大学中医药研究院，天津 300193,3.天津药物研究院，天津 300193,1.天津中医药大学中药学院，天津 300193 |
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| 摘 要： | 穿心莲内酯为从爵床科植物穿心莲中提取得到的二萜内酯类化合物，是中药穿心莲的主要有效成分之一。近年研究表明，其多种衍生物在溶解性等方面优于原型药物，促使含穿心莲内酯及其衍生物的药物在临床上被广泛应用。该文阐述了穿心莲内酯及其衍生物的药代动力学研究进展，以为这一天然活性成分的开发和利用提供依据。
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| 关 键 词： | 穿心莲内酯 衍生物 代谢产物 药代动力学 |
Research progress on pharmacokinetic of andrographolide and its derivatives |
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| Authors: | YANG Ling WANG Kai DING Liqin QIAO Miao HOU Wenbin and QIU Feng |
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| Affiliation: | 1.School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China,1.School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China,1.School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China,1.School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China,1.School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China and 1.School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;2.Institute of Traditional Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;3.Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China |
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| Abstract: | |
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| Keywords: | Andrographolide Derivatives Metabolites Pharmacokinetics |
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