| 孤儿G蛋白偶联受体及其作为新药靶点的重要意义 |
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| 引用本文： | 刘永学,余少平.孤儿G蛋白偶联受体及其作为新药靶点的重要意义[J].中国药理学通报,2003,19(6):601-604. |
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| 作者姓名： | 刘永学 余少平 |
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| 作者单位： | 1. 军事医学科学院放射医学研究所药理毒理室,北京,100850
2. 武汉大学中南医院病理科,武汉,430071 |
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| 基金项目： | 国家自然科学基金,No 30171096 |
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| 摘 要： | 作为膜受体最大的一个家族,G蛋白偶联受体(GPCRs)参与了广泛的生理与病理过程,因而一直是新药发现及研究的最重要靶点。孤儿GPCRs(oGPCRs)是一类内源性配基未定、功能未知的GPCRs,作为创新药物的靶点具有重要的地位和意义。
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| 关 键 词： | 孤儿G蛋白偶联受体 配基 新药靶点 反向药理学 |
| 文章编号： | 1001-1978(2003)06-0601-04 |
| 修稿时间： | 2002年10月5日 |
Orphan G protein-coupled receptors and their significance as novel drug targets |
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| LIU Yong-Xue,YU Shao-Ping.Orphan G protein-coupled receptors and their significance as novel drug targets[J].Chinese Pharmacological Bulletin,2003,19(6):601-604. |
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| Authors: | LIU Yong-Xue YU Shao-Ping |
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| Abstract: | G protein-coupled receptors(GPCRs) are the largest and most diverse group of trans-membrane proteins involved in signal transduction. They have been playing key roles in drug discover-y. Increasing orphan GPCRs (oGPCRs) whose endogenous ligands and functions are still to be identified have been discovered in recent years. It is obvious that oGPCRs might be the most important targets for innovating drugs. |
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| Keywords: | orphan GPCRs ligand drug tar-get reverse pharmacology |
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