| Ca~(2+)信号通道与胰腺炎 |
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| 引用本文： | 王振纲,薛全福.Ca~(2+)信号通道与胰腺炎[J].中国药理学通报,2007,23(3):281-285. |
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| 作者姓名： | 王振纲 薛全福 |
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| 作者单位： | 1. 中国医学科学院基础医学研究所·中国协和医科大学基础医学院,药理学系北京,100005
2. 中国医学科学院基础医学研究所·中国协和医科大学基础医学院,病理生理学系,北京,100005 |
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| 摘 要： | 胰腺炎至今尚缺乏有效的治疗药物。近年来发现胞内Ca2+超负荷能导致胰腺炎的发生。该文综述了胰腺炎早期胰腺腺泡细胞内Ca2+转运的变化和胆盐、乙醇、高脂对其影响,以及咖啡因抑制异常Ca2+信号的作用,并据此提出研究防治药物的新靶点。
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| 关 键 词： | Ca2+信号 胰腺炎 胆汁 乙醇 高脂血症 咖啡因 腺泡细胞 治疗靶点 胆囊收缩素 |
| 文章编号： | 1001-1978（2007）03-0281-05 |
| 修稿时间： | 2006-11-05 |
Ca2+ signaling and pancreatitis |
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| WANG Zhen-gang,XUE Quan-fu.Ca2+ signaling and pancreatitis[J].Chinese Pharmacological Bulletin,2007,23(3):281-285. |
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| Authors: | WANG Zhen-gang XUE Quan-fu |
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| Affiliation: | 1. Dept of Pharmacology,2. Dept of Pathophysiology,Institute of Basic Medical Sciences. Chinese Academy of Medical sciences, School of Basic Medicine, Peking Union Medical College ,Bering 100005, China |
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| Abstract: | To date, pancreatitis lacks of specific pharmacological therapy. Recently, it has been found that cytosolic Ca2 overload causes pancreatitis. This article summarized the earliest events of Ca2 transport in pancreatic acinar cell during pancreatitis and the influence of bile, alcohol, and hyperlipidaemia.Abnormal Ca2 signal can be inhibited by caffeine. Based on these results, potential therapeutic targets are suggested. |
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| Keywords: | Ca2 signal pancreatitis bile alcohol hyperlipidaemia caffeine acinar cell therapeutic targets cholecystokinin |
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