| 丹皮酚对HepA荷瘤小鼠免疫调节和抑瘤作用研究 |
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| 引用本文： | 孙国平,沈玉先,张玲玲,周爱武,魏伟,徐叔云.丹皮酚对HepA荷瘤小鼠免疫调节和抑瘤作用研究[J].中国药理学通报,2003,19(2):160-162. |
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| 作者姓名： | 孙国平 沈玉先 张玲玲 周爱武 魏伟 徐叔云 |
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| 作者单位： | 1. 现在安徽医科大学第一附属医院肿瘤科,合肥,230032
2. 安徽医科大学临床药理研究所,合肥,230022 |
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| 基金项目： | 安徽省自然科学基金资助,No 0 0 0 444 14 |
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| 摘 要： | 目的 研究丹皮酚 ( paeonol)的抗肿瘤作用及其机制。方法 建立小鼠移植性肝癌HepA肿瘤模型 ,观察丹皮酚对肿瘤生长的影响。应用放射免疫法检测小鼠血清中IL 2及TNF α含量 ,同时观察丹皮酚对小鼠脾细胞产生IL 2及腹腔巨噬细胞产生TNF α的影响。结果 丹皮酚对小鼠Hep A肿瘤的生长有抑制作用 ,对IL 2及TNF α的生成有促进作用。结论 丹皮酚可能通过促进IL 2及TNF α的生成而发挥抗肿瘤作用
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| 关 键 词： | 丹皮酚 抗肿瘤作用 TNF-α IL-2 |
| 文章编号： | 1001-1978(2003)02-0160-03 |
| 修稿时间： | 2002年11月7日 |
Study on immunomodulation and antitumor activity of paeonol in HepA tumor mice |
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| SUN Guo-Ping,SHEN Yu-Xian,ZHANG Ling-Ling,ZHOU Ai-Wu,WEI Wei,XU Shu-Yun.Study on immunomodulation and antitumor activity of paeonol in HepA tumor mice[J].Chinese Pharmacological Bulletin,2003,19(2):160-162. |
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| Authors: | SUN Guo-Ping SHEN Yu-Xian ZHANG Ling-Ling ZHOU Ai-Wu WEI Wei XU Shu-Yun |
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| Abstract: | AIM To study immunomodulation and antitumor activity of paeonol. METHODS Paeonol was administered singlely to HepA bearing mice. 14 d later, the inhibition of tumor weight were observed. IL-2 and TNF-α content in serum, IL-2 secretion by splencytes, TNF-α production by PMΦ were measured by RIA. RESULTS Paeonol possess markedly inhibitory activity on the growth of HepA tumor in mice, and IL-2 and TNF-α were induced signficantly. CONCLUSION Paeonol has the effects of antitumor. This effect may be derived from inducing IL-2 and TNF-α production. |
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| Keywords: | IL-2 |
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