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| 灯盏花素对豚鼠心室肌细胞迟发性外向钾电流的影响 | |
| 引用本文： | 王丽娟,王勇,李金鸣.灯盏花素对豚鼠心室肌细胞迟发性外向钾电流的影响[J].中国药理学通报,2002,18(3):326-328. |
| 作者姓名： | 王丽娟 王勇 李金鸣 |
| 作者单位： | 1. 齐齐哈尔医学院药理学教研室,齐齐哈尔,161042 2. 北钢医院药剂科,齐齐哈尔,161041 3. 中国医科大学药理教研室,沈阳,110001 |
| 摘 要： | 目的 观察灯盏花素对心室肌细胞迟发性外向钾离子电流的影响。方法 应用全细胞膜片钳制技术。结果 灯盏花素以剂量依赖的方式增加Ik,0 0 1g·L-1灯盏花素使Ik 增大 4 4 6 % (0 0 1 |
| 关 键 词： | 灯盏花素 膜片钳制技术 迟发性外向钾离子电流(Ik) |
| 文章编号： | 1001-1978(2002)03-0326-03 |
Effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig |
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| WANG Li Juan,WANG Yong,LI Jing Ming.Effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig[J].Chinese Pharmacological Bulletin,2002,18(3):326-328. | |
| Authors: | WANG Li Juan WANG Yong LI Jing Ming |
| Abstract: | AIM To Investigate the effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig. METHOD Using whole cell patch clamp technique. RESULTS Breviscapine enhanced I k dose dependently. Breviscapine with the concentration of 0\^01 and 0\^02 mg·L -1 increased I k by 44.6% and 78.3%,respectively. The effect could be reversed by washing. CONCLUSION Breviscapine can open the K + channel and incrase I k . |
| Keywords: | current patch clamp technique potassium channel |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
