| 胰高血糖素样肽-1在药物成瘾中的作用及机制 |
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| 引用本文： | 张乐,白洁.胰高血糖素样肽-1在药物成瘾中的作用及机制[J].中国药理学通报,2020(4):488-491. |
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| 作者姓名： | 张乐 白洁 |
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| 作者单位： | 昆明理工大学医学院 |
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| 基金项目： | 国家自然科学基金资助项目(No 81660222,U1202227);云南省高校氧化应激与防御重点实验室(No 2018)。 |
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| 摘 要： | 胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种肠降血糖素,具有调节葡萄糖稳态和食欲的作用,与2型糖尿病和肥胖症的发生发展有关。GLP-1主要通过调节胰岛素的分泌和激活GLP-1受体(GLP-1R)而起作用。最近研究发现GLP-1与可卡因、尼古丁、酒精和苯丙胺类等所致的成瘾行为有关。该文主要对GLP-1在药物成瘾中的作用及机制进行综述。
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| 关 键 词： | 胰高血糖素样肽-1 胰高血糖素样肽-1受体 葡萄糖稳态 食欲 胰岛素 药物成瘾 |
Role and mechanism of glucagon-like peptide-1 in drug addiction |
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| ZHANG Le,BAI Jie.Role and mechanism of glucagon-like peptide-1 in drug addiction[J].Chinese Pharmacological Bulletin,2020(4):488-491. |
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| Authors: | ZHANG Le BAI Jie |
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| Affiliation: | (Medical School, Kunming University of Science and Technology, Kunming 650500, China) |
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| Abstract: | Glucagon-like peptide-1(GLP-1)is an incretin which plays a role in regulating glucose homeostasis and appetite,involved in the occurrence and development of type 2 diabetes and obesity.GLP-1 plays the role through regulating insulin secretion and activating the GLP-1 receptor(GLP-1R).Recent studies have found the association between GLP-1 and addictive behaviors caused by cocaine,nicotine,alcohol and amphetamine.This article reviews the role and mechanism of GLP-1 in drug addiction. |
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| Keywords: | glucagon-like peptide-1 glucagon-like peptide-1 receptor glucose homeostasis appetite insulin drug addiction |
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