牛磺酸对大鼠半乳糖性白内障抗氧化作用的探讨

目的 观察牛磺酸对半乳糖性白内障大鼠晶状体抗氧化能力的影响。方法 将36只大鼠分成3组：对照组、白内障组、牛磺酸组，采用d-半乳糖诱发白内障，牛磺酸组诱发当天开始球后注射15％牛磺酸。实验第30天取晶状体测定谷胱甘肽过氧化物酶(GSH-Px)、总抗氧化能力(T-AOC)、维生素E(VE)和超氧阴离子自由基。结果 白内障组与对照组相比，GSH-Px活性、T-AOC及VE含量明显降低，超氧阴离子自由基水平明显升高，而牛磺酸组上述指标有不同程度改善。结论 牛磺酸可保护晶状体免受氧化损伤，对半乳糖性白内障有一定的防治作用。

Preliminary study on the antioxidation effect of taurine in rat of galactose cataract

Obiective To examine the effects of taurine on galactose cataract. Methods 36 rats were divided into 3 groups: control group cataract and taurine group. After inducing galactose cataract, 15% taurine was injected immediately in rats through retroocular of tarrine group. At the 30 th day of experiment , the GSH-Px activity and the levels of T AOC, VE and superoxide anion radical were measured. Results The level of superoxide anion radical was increased and the levels of T AOC and VE, and GSH Px activities were decreased significantly in cataract group compared with control group ( P <0.005 or P <0.001); the level of superoxide anion radical was significantly decreased but the levels of other indexes were increased in taurine group compared with cataract group ( P <0.05 or P <0.001). Conclusion Taurine can protect lens against oxidative stress, and it has certain preventive effect in experimental galactose cataract.