| 橙皮甙在H2O2诱导的大鼠心肌细胞凋亡中的作用 |
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| 引用本文： | 陆红玲,刘永明,徐刚.橙皮甙在H2O2诱导的大鼠心肌细胞凋亡中的作用[J].贵州医药,2010,34(3):212-214. |
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| 作者姓名： | 陆红玲 刘永明 徐刚 |
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| 作者单位： | 1. 遵义医学院生物化学教研室,563003
2. 遵义医学院附属医院胸心血管外科,563003 |
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| 基金项目： | 遵义医学院硕士启动基金资助项目[(2005)011] |
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| 摘 要： | 目的研究橙皮甙对H2O2诱导的大鼠心肌细胞凋亡的影响。方法体外培养SD乳鼠心肌细胞，用H2O2诱导培养的大鼠心肌细胞凋亡，制造心肌细胞凋亡模型。设立对照组、模型组、溶媒组、橙皮甙低剂量组（终末浓度10^-5mmol／L）、中剂量组（终末浓度10^-5mmol／L）、高剂量组（终末浓度10^-5mmol／L），于药物作用4、8、12h后用流式细胞仪检测细胞凋亡情况。结果橙皮甙组与模型纽比较有抑制SD乳鼠心肌细胞凋亡的作用，且效应随橙皮甙浓度的增加和时间的延长而增强（P〈0．01）。结论橙皮甙对H2O2诱导的心肌细胞凋亡有抗凋亡保护心肌细胞的作用。
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| 关 键 词： | 心肌细胞凋亡 橙皮甙 过氧化氢 |
Effects of hesperidin on rat cardiomyocytes apoptosis induced by H2O2 |
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| Lu Hongling,Liu Yongming,Xu Gang.Effects of hesperidin on rat cardiomyocytes apoptosis induced by H2O2[J].Guizhou Medical Journal,2010,34(3):212-214. |
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| Authors: | Lu Hongling Liu Yongming Xu Gang |
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| Affiliation: | Lu Hongling,Liu Yongming,Xu Gang.Department of Biochemistry,Zuiyi Medical College.Zunyi 563003,China. |
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| Abstract: | Objective To study the effects of hesperidin to rat cardiomyocytes apoptosis.Methods Primary cultured neonatal SD rat cardiomyocytes,H2O2 induced cultured cardiomyocytes to establish apoptosis model,apoptosis was evaluated by tunel method after cultured cardiomyocytes was treated by different concentration hesperidin for 4,8,12h.At the same time,set up control group,model group and menstruum group.ResultsCompared with model group,there were the inhibit effects in hesperidin group in different concentration.... |
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| Keywords: | Apoptosis Hesperidin Hydrogen peroxide （ H2O2 ） |
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