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阿卡波糖和二甲双胍治疗2型糖尿病的比较
引用本文:冯继明,余燕敏,冯方.阿卡波糖和二甲双胍治疗2型糖尿病的比较[J].中国新药与临床杂志,2001,20(4):280-282.
作者姓名:冯继明  余燕敏  冯方
作者单位:上海市第二人民医院上海 200011
摘    要:目的 :比较阿卡波糖和二甲双胍治疗 2型糖尿病的疗效。方法 :选择 6 0例 2型糖尿病病人 ,分为阿卡波糖组 30例 (男 ,女各 15例 )口服阿卡波糖 50~ 10 0mg ,tid。另 30例为二甲双胍组 (男性 16例 ,女性 14例 ) ,口服二甲双胍 2 50~ 50 0mg ,tid ,均用 6wk。结果 :阿卡波糖和二甲双胍均能明显降低空腹和餐后血糖 ,阿卡波糖的有效率分别为 83%和97% ,二甲双胍的有效率分别为 87%和 73%。降低餐后血糖的作用 ,阿卡波糖优于二甲双胍 (P <0 .0 1) ,而降低胆固醇的作用 ,阿卡波糖不如二甲双胍 (P <0 .0 1)。阿卡波糖不良反应为腹胀和排气增多 ,发生率为 17% ;二甲双胍为恶心和腹泻 ,发生率为 13%。结论 :阿卡波糖治疗 2型糖尿病安全有效 ,降低餐后血糖优于二甲双胍

关 键 词:阿卡波糖  二甲双胍  非胰岛素依赖型糖尿病
文章编号:1007-7669(2001)04-0280-03

Acarbose vs metformin in treating non-insulin dependent diabetes mellitus
FENG Ji Ming,Yu Yan Min,FENG Fang.Acarbose vs metformin in treating non-insulin dependent diabetes mellitus[J].Chinese Journal of New Drugs and Clinical Remedies,2001,20(4):280-282.
Authors:FENG Ji Ming  Yu Yan Min  FENG Fang
Abstract:AIM: To compare the efficacy of acarbose and metformin in treating non insulin dependent diabetes mellitus (NIDDM). METHODS: Sixty patients with NIDDM were divided into two groups. Thirty patients (M15, F15; age 61 a± s 13 a) were treated with acarbose 50-100 mg po , tid×6 wk; and after 30 patients (M16, F14; age 60±12 a) with metformin 250-500 mg, po , tid×6 wk as control. RESULTS: The fasting and 2 h postprandial blood glucose were remarkably lowered after therapy by acarbose and metformin. The effective rate of acarbose were 83 % and 97 %; and the effective rate of metformin were 87 % and 73 %. Acarbose was superior to metformin (in reducing 2 h postprandial blood glucose, P <0.01). And acarbose aws worse than metformin in lowering total cholesterol (TC)( P <0.01). The rates of adverse reaction were respectively 17 % and 11 %. CONCLUSION: Acarbose is a safe and effective drug in the treatment of NIDDM.
Keywords:acarbose  metformin  non  insulin dependent diabetes mellitus    [
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