| 吉非贝齐与非诺贝特降脂疗效比较 |
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| 引用本文： | 陈斌,韩琴琴,陈曙霞,梅尚义,胡义桥,陈淑良.吉非贝齐与非诺贝特降脂疗效比较[J].中国新药与临床杂志,1995(2). |
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| 作者姓名： | 陈斌 韩琴琴 陈曙霞 梅尚义 胡义桥 陈淑良 |
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| 作者单位： | 上海医科大学附属中山医院，上海市心血管病研究所，上海第二医科大学附属仁济医院，上海市纺织工业局第三医院 |
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| 摘 要： | 高脂血症２１０例，其中１０９例（男性６０例，女性４９例；年龄５８±ｓ８ａ）采用吉非贝齐６００ｍｇ，ｐｏ，ｂｉｄ共治疗１２ｗｋ；另１组１０１例（男性６６例，女性３５例；年龄５９±８ａ）采用非诺贝特１００ｍｇ．ｐｏ，ｔｉｄ共１２ｗｋ。结果：降三酰甘油，降总胆固醇及升高高密度脂蛋白胆固醇，吉非贝齐组依次为５３．０％，１９．４％及２６．８％，（Ｐ值均为＜０．０１），非诺贝特依次为４１．０％，２２．０％及２２．０％（Ｐ值均＜０．０１），２组组间比较无差异（Ｐ＞０．０５）；前者有４例，后者有５例一过性ＧＰＴ（ＡＬＴ）升高。
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| 关 键 词： | 吉非贝齐 非诺贝特 血脂过多 |
Gemfibrozil vs fenofibrate in treating hyperlipidemia |
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| CHEN Bin,HAN Qin-Qin.Gemfibrozil vs fenofibrate in treating hyperlipidemia[J].Chinese Journal of New Drugs and Clinical Remedies,1995(2). |
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| Authors: | CHEN Bin HAN Qin-Qin |
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| Abstract: | In 210 patients with hyperlipemia,109 patients(M60,F49;age 58±s 8 a) were treated with gemfibrozil 600 mg,po,bid×12 wk,and 101 patients(M66,F35;age 59±8a) were treated with fenofibrate 100 mg,po,bid×12 wk.Results shwed that in gemfibrozil group the levels of triglyceride(TG) and total cholesterol(TC) decreased 53.0%and 19.4% respectively, and high density lipoprotein cholesterol(HDL-ch) increased 26.8%(all P<0.01).In fenofibrate group,the levels of TG and TC decreased 41.0% and 22.0%respectively and HDL-ch increased 22.0% (all P<0.01).But the difference between the two groups was non significant (P>0.05).No serious side effects were found during the therapeutic period,but 4 patients in gemfibrozil group and 5 patients in fenofibrate group had transient increase of GPT activity. |
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| Keywords: | gemfibrozil procetofen hyperlipidemia |
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