| 地尔硫治疗原发性高血压27例 |
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| 引用本文： | 邱慧丽,王宪衍,范明昌,龚兰生,丁培.地尔硫治疗原发性高血压27例[J].中国新药与临床杂志,1990(5). |
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| 作者姓名： | 邱慧丽 王宪衍 范明昌 龚兰生 丁培 |
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| 作者单位： | 上海第二医科大学上海市高血压研究所，上海第二医科大学上海市高血压研究所，上海第二医科大学上海市高血压研究所，上海第二医科大学上海市高血压研究所，上海延安制药厂 上海200025，上海200025，上海200025，上海200025 |
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| 摘 要： | 本文用随机双盲组间对照的方法,对53例原发性高血压进行治疗对比.地尔硫组27例(男20例,女7例;年龄50±SD7yr;病程14±7yr),用最大剂量270mg/d,4wk为一疗程。维拉帕米组26例(男25例,女1例;年龄52±6yr病程14±8yr)用最大剂量360mg/d,4wk为一疗程。总有效率前者大于后者(85％,46％)但差异不显著,降压幅度亦是前者大(2.0/2.0kPa,1.0/1.0kPa,P<0.01,0.05)2药均有升高HDL-ch的作用,副作用均较轻.
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| 关 键 词： | 地尔硫/治疗应用 维拉帕米/治疗应用 高血压/药物疗法 高密度脂蛋白类 |
Diltiazem treatment of essential hypertension in 27 patients |
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| QIU Hui-Li,WANG Xian Yan,FAN Ming-Chang,DIN Pie,GONG Lan-Sheng.Diltiazem treatment of essential hypertension in 27 patients[J].Chinese Journal of New Drugs and Clinical Remedies,1990(5). |
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| Authors: | QIU Hui-Li WANG Xian Yan FAN Ming-Chang DIN Pie GONG Lan-Sheng |
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| Abstract: | In a randomized double-blind therapeutic trial, diltiazem or verapamil was given to 53 patients with essential hypertension for 4 wk. Twenty-seven patients (M20,F 7;age 50+7 yr; duration of hypertension 14+7 yr)received maximal diltiazem 270 mg/d,and 26 patients(M 25,F 1;age 52+6 yr; duration of hypertension 14+8 yr) received maximal verapamil 360 mg/d.In diltiazem group,the response rate was 85%, while in verapamil group 46%(P>0.05).The blood pressure in the former was reduced more definitely than that in the latter(2.0/2.0 vs 1.0/1.0 kPa,P<0.01,P<0.05). The serum HDL-ch was increased without significance in both groups. No serious adverse effects were noticed with both agents. |
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| Keywords: | diltiazem/therapeutic use verapamil / therapeutic use hypertension/drug therapy HDL lipoproteins |
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