| 树突状细胞疫苗注射治疗慢性乙型肝炎后外周血T细胞亚群的变化 |
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| 引用本文： | 焦栓林,卢留斌,刘毅.树突状细胞疫苗注射治疗慢性乙型肝炎后外周血T细胞亚群的变化[J].实用医药杂志(山东),2009,26(3). |
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| 作者姓名： | 焦栓林 卢留斌 刘毅 |
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| 作者单位： | 153医院东区感染科,河南郑州,450007
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| 摘 要： | 目的研究轻度慢乙肝患者经树突状细胞疫苗治疗后外周血中T细胞亚群的改变。方法32例轻度慢乙肝患者,每次注射>106乙肝疫苗冲击树突状细胞,1次/月,共12次。于治疗前后利用流式细胞仪测定患者外周血中T细胞亚群。结果在树突状细胞疫苗治疗后有应答反应的20例患者中可见CD4+T细胞和CD8+CD28+T细胞明显增加,而CD8+T细胞和CD8+CD28-T细胞显著降低。结论树突状细胞疫苗有可能活化慢乙肝患者的免疫反应,对其治疗有一定疗效。
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| 关 键 词： | 慢性乙型肝炎 树突状细胞 T细胞亚群 免疫治疗 |
Study on the curative efficacy of DC vaccine: the change of T cell subsets in perpheral Mood from mild chronic hepatitis B patients |
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| JIAO Shuan-lin,LU Liu-bin,LIU Yi.Study on the curative efficacy of DC vaccine: the change of T cell subsets in perpheral Mood from mild chronic hepatitis B patients[J].Practical Journal of Medicine & Pharmacy,2009,26(3). |
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| Authors: | JIAO Shuan-lin LU Liu-bin LIU Yi |
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| Abstract: | Objective To study the chenge of T cell subsets in peripheral blood from mild chronic hepatitis B(CHB)patients after DC(dendritic cell)vaccine treatment.Method HBsAg vaccine-pulsed DC(>106)were injected into 32 mild CHB patients once a month.The therapy was repeated 12 times.T cell subsets in perpheral blood was determined after DC vaccine treatment with flow cytometry.Result The percentage of CD4+ and CD8+ CD28+ T cells were significantly increased,however the percentage of CD8+ and CD8+ CD28-T cells were decreased after DC vaccine treatment in 20/32 response group patients.Conclusion DC vaccine is able to active immune response and might be effective to treatment of CHB infection. |
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| Keywords: | Chronic hepatitis B Dendritic cell T cell subset Immunotherapy |
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