肝细胞癌癌旁组织nm23-H1蛋白表达与门静脉转移的关系

目的探讨肝细胞癌(HCC)癌旁组织中nm23-H1表达强度与HCC门静脉转移的关系。方法选择HCC111例,其中门静脉转移、无肝内外转移者各33例,肝外转移45例,另选肝血管瘤(HH)患者30例设为对照,用免疫组化方法检测上述患者癌旁或瘤旁组织的nm23-H1蛋白的表达,采用等级相关分析探讨nm23-H1蛋白表达与门静脉转移之间的关系。结果HCC伴门静脉转移组nm23-H1蛋白表达程度明显低于HCC无肝内外转移组及伴肝外转移组(P<0.05),HCC无肝内外转移组及伴肝外转移组nm23-H1蛋白表达程度明显低于对照组(P<0.05),nm23-H1蛋白表达程度在HCC无肝内外转移组与伴肝外转移组之间无显著性差异(P>0.05)。结论HCC癌旁组织nm23-H1表达程度与门静脉转移有关,nm23-H1表达程度低发生门静脉转移的可能性大。

The relationship between expressions of nm23-H1 protein in surrounding liver tissue of hepatocellular carcinoma and portal vein metastasis of this disease

Objective To investigate the relationship between the expressions of nm23-H1 in surrounding liver tissue of hepatocellular carcinoma(HCC) and portal vein metastasis of this disease.Methods The expressions of nm23-H1 being procured with immunohistochemistry in surrounding liver tissue of 111 cases. including portal vein metastasis of 33 cases.extra-hepatic metastasis of 45 cases.and 33 cases without metastasis. and 30 cases of hepatic haemangioma(HH) were investigated.then the relationship between the expressions of nm23-H1 in surrounding liver tissue of HCC and portal vein metastasis of this disease was investigated using statistical method of rank correlation.Results The expressions of nm23-H1 in surrounding liver tissue of HCC in the group of HCC with portal vein metastasis was obviously lower than in the group of HCC without extra-and inter-hepatic metastasis and the group of HCC with extra-liver metastasis(P<0.05).and that in the group of HCC without extra-and inter-hepatic metasitasis and the group of HCC with extra-liver metastasis. but no relativity was found between themselves(P>0.05).was lower than in surrounding liver tissue of HH in the group of HH(P<0.05).Conclusion The expressions of nm23-H1 in surrounding liver tissue of HCC is related to portal vien metastasis of HCC. and the more lower of expressions of nm23-H1 in surrounding liver tissue of HCC proceeds the more higher of possibility of portal vein metastasis.