| 立体定向技术制作大鼠脑出血模型评价 |
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| 引用本文： | 刘胜达,周志明,吴家幂.立体定向技术制作大鼠脑出血模型评价[J].中国现代医药杂志,2003,5(1):31-32. |
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| 作者姓名： | 刘胜达 周志明 吴家幂 |
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| 作者单位： | 1. 100076,北京,中国航天科技集团公司总医院
2. 皖南医学院戈矶山医院 |
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| 摘 要： | 目的 通过向大鼠注入自体新鲜不凝血制作脑出血模型,找出一种操作简便、重复性好的脑出血动物模型。方法 参照Yang和Xue的方法,通过立体定向技术注入自体不凝血制备大鼠尾状核出血模型,观察术后血肿形态、脑组织含水量动态变化。结果 血肿形态多为圆形或椭圆形,大小相近。脑组织含水量出血后12h升高,72h达高峰,2w时降至正常。结论 该模型是研究实验性脑出血后脑水肿较为理想的模型,重复性好、易于制备。
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| 关 键 词： | 脑出血 动物模型 脑水肿 大鼠 |
| 修稿时间： | 2002年9月17日 |
Evaluation of stereo-orientation technique making ICH animal model |
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| Liu Shengda,Zhou Zhiming,Wu Jiami.Evaluation of stereo-orientation technique making ICH animal model[J].Modern Medicine Journal of China,2003,5(1):31-32. |
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| Authors: | Liu Shengda Zhou Zhiming Wu Jiami |
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| Affiliation: | Liu Shengda,Zhou Zhiming,Wu Jiami. General hospital of CASC,Beijing 100076 |
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| Abstract: | Objective To infuse fresh quantitative autologous blood build up rat ICH model,so as to find a conveniently making, easily repeating rat ICH model. Methods In accordance with Yang and Xue, stereotaxic apparatus and infuse fresh quantitative autologous blood into the left caudate nucleus was utilized to build up rat ICH model, and observe the form of hematoma and the dynamic change of brain water after ICH. Results The form of hematoma was majority round , oval-shap. The brain water increase at 6h after ICH,and there was statistical significance at 12h (P<0. 05), and it peaked at 72h , at 2w it decreased to normal level ( P>0. 05). Conclusions The model is ideal to study the edema formation after ICH and easily to repeat and make. |
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| Keywords: | ICH Animal model Brain edema Rat |
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