氟比洛芬酯复合酒石酸布托啡诺在腔镜甲状腺切除术后的镇痛效果研究

目的评价氟比洛芬酯复合酒石酸布托啡诺用于腔镜甲状腺切除术后多模式镇痛效果。方法选择60例拟行腔镜下甲状腺切除手术的成年女性患者,ASAⅠ~Ⅱ级,随机分为3组:对照组(C组):注射用芬太尼0.1mg稀释至10ml,拔管后即刻静脉缓慢推注;氟比洛芬酯组(F组):氟比洛芬酯100mg,拔管后即刻静脉缓慢推注;氟比洛芬酯复合酒石酸布托啡诺组(FB组):氟比洛芬酯注射液50mg复合酒石酸布托啡诺1mg稀释至10ml,拔管后即刻静脉缓慢推注。观察静脉给药后0、2、4、8、12、24h的镇痛、镇静评分及不良反应发生率。结果与C组比较,F组在术后4h镇痛评分低;FB组在术后2、4及8h镇痛评分低,2及4h镇静评分高(P<0.05)。与F组比较,FB组在术后2及4h镇痛评分低,在2h镇静评分高(P<0.05)。术后恶心呕吐、呼吸抑制、皮肤瘙痒等不良反应发生率差异无统计学意义(P>0.05)。结论氟比洛芬酯复合酒石酸布托啡诺静脉注射安全有效,能够更好的满足腔镜甲状腺切除术后早期镇痛,且镇静效果好。

Effect of flurbiprofen axetil compound butorphanol on postoperative multimodel analgesia in patients undergoing endoscopic thyroidectomy

Objective To assess the multimodel analgesia effect of flurbiprofen axetil compound butorphanol on postoperative for patients undergoing endoscopic thyroidectomy. Methods The clinical data of 60 selective underwent an endoscopic thyroidectomy surgery patients Under general anesthesia were randomized into 3 groups, control group(C)and Flurbiprofen Axetil group (F)received intravenous of fentanyl 0.1mg and flurbiprofen axetil 100mg after tracheal decannulation respectively, and Flurbiprofen Axetil compound Butorphanol group(FB)received intravenous of flurbiprofen axetil 50mg and butorphanol 1mg after tracheal decannulation. And effect of analgesia were assessed by Visual Analogue Scale and Ramesy Scale at 0,2,4,8,12 and 24h in post-anesthesia care unit and side effects were assessed. Results The pain VAS in group F were lower than group C at 4h after operation(P<0.05).The pain VAS in group FB were lower at 2,4,and 8h compare with group C,and sedation depth were higher at 2 and 4h,compare with group F(P<0.05),the pain VAS in group FB were lower at 2 and 4h(P<0.05),and sedation depth were higher at 2h(P<0.05), side effects was no statistically significant in 3 groups(P>0.05). Conclusion Flurbiprofen axetil compound butorphanol intravenous is safe and effective,and produce a higher analgesia and sedation in patients undergoing endoscopic thyroidectomy.