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| 改性壳聚糖膜在兔眼中的降解及组织病理学观察 | |
| 引用本文： | 韦萍,王爱勤,刘斌,高自芳,李晓林.改性壳聚糖膜在兔眼中的降解及组织病理学观察[J].中国生化药物杂志,2004,25(3):133-135. |
| 作者姓名： | 韦萍 王爱勤 刘斌 高自芳 李晓林 |
| 作者单位： | 1. 兰州市第一人民医院,眼科,甘肃,兰州,730050 2. 中国科学院,兰州化学物理研究所,甘肃,兰州,730000 3. 兰州军区兰州总医院,病理科,甘肃,兰州,730050 |
| 基金项目： | 甘肃省科学基金资助项目 (GS0 0 2 A43 0 5 2 ) |
| 摘 要： | 目的了解兔眼中壳聚糖膜的降解与生物相容性 ,观察眼组织的病理学变化。方法对兔眼实施小梁切除术 ,将不同相对分子质量改性壳聚糖膜 ,植入板层巩膜瓣下 ,分别于术后 1、4、1 2周处死 ,摘除眼球 ,病理切片 ,观察组织反应。结果在植入早期 1、4周时 ,局部组织出现明显的炎症反应 ,随时间的推移 ,改性壳聚糖膜的降解速度加快 ,1 2周时 ,已降解为碎屑状 ,炎症反应基本消失。结论改性壳聚糖膜植入兔眼内可降解吸收 ,对兔眼组织不产生病理性损害 |
| 关 键 词： | 改性壳聚糖膜 小梁切除术 生物降解 病理 |
| 文章编号： | 1005-1678(2004)03-0133-03 |
| 修稿时间： | 2003年6月30日 |
Biodegradation and tissue observation of modification chitosan film in rabbit eyes |
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| WEI Ping ,WANG Ai qin ,LIU Bin ,GAO Zi fang ,LI Xiao lin.Biodegradation and tissue observation of modification chitosan film in rabbit eyes[J].Chinese Journal of Biochemical Pharmaceutics,2004,25(3):133-135. | |
| Authors: | WEI Ping WANG Ai qin LIU Bin GAO Zi fang LI Xiao lin |
| Affiliation: | WEI Ping 1,WANG Ai qin 2,LIU Bin 3,GAO Zi fang 3,LI Xiao lin 1 |
| Abstract: | PurposeTo study the biodegradation of modified chitosan film in rabbit eyes and the change of tissue.MethodsAfter the trabeculectomy was used in the rabbit eyes, and the chitosan films with different molecular weight were implanted in intertaminal scleral flap, the rabbits were killed and ophthalmectomy was performed to observe the change of tissue at the first, fourth and twelveth week separately. ResultsThe inflammation in the eyes was obvious in local tissue after 1 week and 4 weeks, the degradation rate was higher than that of at other times and the inflammation basically subsided after 12 weeks.ConclusionThe modified chitosan film was degraded and absorbed in the rabbit eyes. It isn′t pathological lesion to tissue in rabbit eyes. |
| Keywords: | Chitosan film trabeculectomy degradation pathology |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
