163例药品不良反应报告分析

目的:了解盐城市第一人民医院药品不良反应(ADR)发生的特点。方法:对2008—2010年收集到的163例ADR报告进行综合分析。结果:163例ADR报告中,引发ADR的男女比例为1∶1.30,>60岁为高发年龄段;静脉滴注给药为引发ADR的主要途径,有118例(占72.40%);引发ADR的药品种类位居前2位的是抗菌药物(84例,占51.53%)、中药制剂(19例,占11.66%);抗菌药物中,发生ADR的总病例数位居前3位的是氟喹诺酮类(27例,占32.14%)、头孢菌素类(19例,占22.62%)、大环内酯类(17例,占20.24%);ADR的临床表现以皮肤及其附件损害最为常见。结论:为保障临床用药安全、合理,应重视ADR,加强监测报告工作。

Adverse Drug Reaction Reports:Analysis of 163 Cases

OBJECTIVE： To probe into the characteristics of the adverse drug reaction（ADR） occurred in Yancheng First People＇s Hospital.METHODS： A total of 163 ADR reports collected during 2008-2010 period were given an aggregate analysis.RESULTS： Of the 163 cases,the ratio of males to females was 1∶1.30 with the patients aged over 60 years took the highest proportion;118 cases（72.40%） were induced by IV drip infusion.The ADR were predominantly induced by antibacterials（84 cases,51.53%） followed by Chinese medicine（19 cases,11.66%）;of all the antibacterials,quinolones took the lead（32.14%） followed by cephalosporins（22.62%） and macrolides（20.24%）.Damage of skin and its accessory was the most common clinical manifestation of the ADR.CONCLUSION： It is important to tighten monitoring and reporting on ADR in an effort to ensure clinical safe and rational drug use.