胃苏颗粒联合四联疗法治疗幽门螺杆菌阳性慢性萎缩性胃炎的疗效观察

目的:探讨胃苏颗粒联合四联疗法治疗幽门螺杆菌(Hp)阳性慢性萎缩性胃炎(chronic atrophic gastritis,CAG)的临床疗效。方法:采用随机数表法将东莞市人民医院2017—2019年收治的100例Hp阳性CAG患者分为对照组(n=50)和研究组(n=50)。对照组患者给予四联疗法治疗,研究组患者在对照组治疗的基础上给予胃苏颗粒治疗,两组患者均连续治疗2周。治疗后统计两组患者的临床疗效和Hp根除情况,观察治疗前后血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、白细胞介素1(IL-1)、白细胞介素6(IL-6)及C反应蛋白(CRP)水平,比较两组患者治疗过程中不良反应发生情况。结果:研究组患者的临床总有效率为92.00%(46/50),明显比对照组的74.00%(37/50)高,差异有统计学意义(P<0.05)。治疗后,对照组患者的Hp根除率为70.00%(35/50),研究组患者的Hp根除率为88.00%(44/50),研究组患者的Hp根除率明显较对照组高,差异有统计学意义(P<0.05)。两组患者治疗后的血清PGⅠ、PGⅠ/PGⅡ水平明显高于治疗前,血清IL-1、IL-6及CRP水平明显低于治疗前;同时,研究组患者治疗后血清PGⅠ、PGⅠ/PGⅡ水平明显高于对照组,血清IL-1、IL-6及CRP水平明显低于对照组,差异均有统计学意义(P<0.05)。对照组、研究组患者的不良反应发生率分别为8.00%(4/50)、10.00%(5/50),差异无统计学意义(χ²=0.122,P=0.727)。结论:胃苏颗粒联合四联疗法治疗Hp阳性CAG的临床疗效显著,能够提高Hp根除率,改善胃黏膜分泌功能,抑制炎症反应,且安全性较好。

Efficacy of Weisu Granules Combined with Quadruple Therapy in the Treatment of Helicobacter Pylori Positive Chronic Atrophic Gastritis

OBJECTIVE:To investigate the clinical efficacy of Weisu granules combined with quadruple therapy in the treatment of Helicobacter pylori(Hp)positive chronic atrophic gastritis(CAG).METHODS:Totally 100 patients with Hp positive CAG admitted into Dongguan People’s Hospital from 2017 to 2019 were extracted to be divided into the control group(n=50)and the study group(n=50)via the random number table.The control group was treated with quadruple therapy,while the study group received Weisu granules on the basis of the control group.Patients in both groups were treated continuously for 2 weeks.After treatment,the clinical efficacy and eradication rate of Hp of two groups were counted.Serum pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),interleukin 1(IL-1),interleukin6(IL-6)and C-reactive protein(CRP)levels of two groups before and after treatment were observed.The incidence of adverse drug reactions was compared between two groups.RESULTS:The total effective rate of the study group was92.00%(46/50),significantly higher than that of the control group 74.00%(37/50),the difference was statistically significant(P<0.05).After treatment,the eradication rate of Hp was 70.00%(35/50)in the control group and88.00%(44/50)in the study group,the eradication rate of Hp in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the serum PGⅠ,PGⅠ/PGⅡof two groups were significantly higher than those before treatment,and serum levels of IL-1,IL-6 and CRP were significantly lower than those before treatment.After treatment,the serum PGⅠ,PGⅠ/PGⅡof the study group were significantly higher than those of the control group,and the serum levels of IL-1,IL-6 and CRP were significantly lower than those of the control group,the differences were statistically significant(P<0.05).The incidence of adverse drug reactions in the control group and the study group were respectively 8.00%(4/50)and 10.00%(5/50),the difference was not statistically significant(χ²=0.122,P=0.727).CONCLUSIONS:The clinical efficacy of Weisu granules combined with quadruple therapy in the treatment of Hp is significant,which can significantly improve the eradication rate of Hp and the secretion function of gastric mucosa,inhibit the inflammatory response with higher safety.