Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-one derivatives. |
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| Authors: | A Chimirri A De Sarro G De Sarro R Gitto M Zappalà |
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| Affiliation: | Dipartimento Farmaco-Chimico, Università di Messina, Italy. chimirri@pharma.unime.it |
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| Abstract: | A number of novel 1H-pyrrolo1,2-a]benzimidazol-1-one derivatives were prepared and their anticonvulsant properties evaluated. The new synthesized compounds proved to possess anticonvulsant effects depending on the nature of substituents at C-6, C-2, and C-3a positions of the polycyclic system. In particular, the 6-chloro-3a-(p-tolyl)-2,3,3a,4-tetrahydro-1H-pyrrolo1,2-a]benzimidazol-1-one derivative (22) displayed potency fivefold higher than unsubstituted compound (13). |
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