The implications of non-linear red blood cell partitioning for the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

The implications of non-linear red blood cell partitioning for the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine

Authors:	E SNOECK P JACQMIN A VAN PEER M DANHOF K VER DONCK H VAN BELLE R WOESTENBORGHS R CRABBÉ R VAN GOOL A DUPONT J HEYKANTS

Affiliation:	Department of Drug Metabolism and Pharmacokinetics, Leiden University, Leiden, The Netherlands;Department of Biochemistry, Leiden University, Leiden, The Netherlands;Department of Scientific Support, Leiden University, Leiden, The Netherlands;Department of Clinical Research and Development, Janssen Research Foundation, Beerse, Belgium, Leiden University, Leiden, The Netherlands;Division of Pharmacology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands

Abstract:

Keywords:	draflazine nucleoside transport inhibitor non-linear red blood cell partitioning pharmacokinetics pharmacodynamics adenosine breakdown inhibition red blood cell occupancy