| 姜黄素抗肿瘤作用机制的研究进展 |
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| 引用本文： | 黄果,王佑权,谭米多,等.姜黄素抗肿瘤作用机制的研究进展[J].肿瘤药学,2014(5):328-331. |
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| 作者姓名： | 黄果 王佑权 谭米多 等 |
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| 作者单位： | 南华大学第二临床学院,湖南衡阳421001 |
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| 摘 要： | 多种恶性肿瘤细胞中表达细胞凋亡抑制蛋白（IAPs）,如：Survivin、NAIP、XIAP、Livin等,同样表达抗细胞凋亡Bcl-2家族蛋白。IAPS介导的凋亡抑制可能是肿瘤细胞耐药而存活的原因之一;Bcl-2家族蛋白在抗肿瘤凋亡及促其凋亡中发挥作用。姜黄素具有抗炎、抗氧化、抑制血管新生等,可以通过调控蛋白表达及相关信号通路促进细胞凋亡、抗肿瘤作用。
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| 关 键 词： | 姜黄素 IAPS Bcl-2家族蛋白 信号通路 癌细胞 细胞凋亡 |
The Research Progress of Curcumin Antitumor Mechanism |
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| HUANG Guo,WANG Youquan,TAN Miduo,XIE Haihui,LI Wei,LIU Guowen.The Research Progress of Curcumin Antitumor Mechanism[J].Anti-Tumor Pharmacy,2014(5):328-331. |
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| Authors: | HUANG Guo WANG Youquan TAN Miduo XIE Haihui LI Wei LIU Guowen |
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| Affiliation: | (The Second Affiliated Hospital of the University of South China, Hengyang, Hunan, 421001, China) |
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| Abstract: | A variety of tumor cells have expression of the inhibitor of apoptosis proteins（IAPs） such as survivin,NAIP,XIAP and Livin protein,as well as expression of resistance-to-apoptosis Bcl-2 family protein.The apoptosis inhibition mediated by IAPS may be one of the reasons for drug-resistant tumor cell and its survival.The Bcl-2 family proteins also play a role in anti-tumor apoptosis and promote their apoptosis proteins.Curcumin has functions like anti-inflammatory,antioxidant,inhibition of angiogenesis and so on.It can promote cell apoptosis and strengthen the antitumor effects through its regulation of protein expressions and related signaling pathways. |
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| Keywords: | Curcumin IAPS Bcl-2 family proteins Signaling pathway Cell apoptosis |
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