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Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma |
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| Authors: | Bryce A Harrison Zheng Y Almstead Hugh Burgoon Michael Gardyan Nicole C Goodwin Jason Healy Ying Liu Ross Mabon Brett Marinelli Lakshman Samala Yulian Zhang Terry R Stouch N Andrew Whitlock Suma Gopinathan Beth McKnight Shuli Wang Nita Patel Alan G E Wilson Brian D Hamman Dennis&#;S Rice David B Rawlins | |
| Affiliation: | †Department of Medicinal Chemistry, Lexicon Pharmaceuticals, 350 Carter Road, Princeton, New Jersey 08540, United States;‡Department of Pharmaceutical Discovery, §Department of Drug Metabolism, Pharmacokinetics, and Toxicology and ∥Department of Ophthalmology, Lexicon Pharmaceuticals, 8800 Technology Forest Place, The Woodlands, Texas 77381, United States | |
| Abstract: | ||
| Keywords: | LX7101 glaucoma kinase ROCK inhibitor LIM-kinase | |
