羽叶三七叶中甙类成分的研究

从羽叶三七叶中分离到十三种甙类成分,经FAB-MS,¹³CNMR谱,双照射¹HN-MR谱,¹H-¹H COSY谱及与标准品直接对照,证明十一种为已知化合物,分别为人参皂甙F₁(Ⅰ),F₂(Ⅱ),F₃(Ⅲ),R_g2(Ⅳ),R_a(Ⅴ),R_d(Ⅵ),R_b1(Ⅷ),R_b3(Ⅷ),24(S)-假人参甙F₁₁(Ⅸ),人参黄酮(Ⅹ)和珠子参甙F₁(Ⅺ);另外两种为新的达玛烷型皂甙,命名为羽叶三七甙F₁(Ⅻ)和F₂(ⅫⅠ),并确定其化学结构。同时修正珠子参甙F₃的结构。进一步阐明人参黄酮甙结构中的两个糖的连接方式。

STUDIES ON SAPONINS FROM THE LEAVES OF PANAX JAPONICUS VAR. BIPINNATIFIDUS(SEEM.)WU ET FENG

Two new saponins, bipinnatifidusoside F₁(Ⅻ) and F₂(ⅩⅢ), were isolated along with eleven known saponins from the dried leaves of Panax japonicus var.bipinnatifidus(Seem.)Wu et Feng collected in the Range of Qinling Mountains in China. By spectrometric analysis(FAB-MS,¹H and ¹³CNMR,¹H-¹H COSY), their structures were elucidated as dammar-25(26)-ene-3β, 12β, 20(S), 2ξ- tetraol-(20-O-β-D-glucopyranosyl)-3-O-β-D-glucopyranosyl(1-2)-β-D-glucopyranoside(bipinnatifidusoside F₁) and dammar-22(23) ene-3β,12β, 20(S), 24ξ-tetraol-(20-O-β-D-glucopyranosyl)-3-O-β-D-glucopyranosyl(1-2)-β-D-glucopyranoside (bipinnatifidusoside F₂), respectively. The known saponins were identified as ginsenoside F₁,F₂,F₃,Rg₂,Re,Rd,Rb₁,Rb₃, 24(S)-pseudoginsenoside F₁₁,panasenoside and majoroside F₁.Compared with bipinnatifidusoside F₂,majoroside F₃ was corrected as dammar-22 (23)-ene-3β,12β,20(S), 24ξ-tetraol-(20-O-β-D-glucopyranosyl)-3-O-β-D-glucopyranoside.