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羟基红花黄色素A对血小板活化因子的拮抗作用
引用本文:臧宝霞,金鸣,司南,张彦,吴伟,朴永哲.羟基红花黄色素A对血小板活化因子的拮抗作用[J].药学学报,2002,37(9):696-699.
作者姓名:臧宝霞  金鸣  司南  张彦  吴伟  朴永哲
作者单位:1. 北京市心肺血管疾病研究所药理研究室,北京,100029
2. 北京中医药大学中药学院,北京,100029
基金项目:国家自然科学基金 ( 396 70 884 ),北京市跨世纪科技人才工程及北京市高科技实验室课题资助项目
摘    要:目的观察羟基红花黄色素A(HSYA)对血小板活化因子(PAF)的拮抗作用.方法以放射受体结合试验观察HSYA抑制3H]PAF与家兔洗涤血小板(WRP)特异性结合的作用,以比浊法观察HSYA抑制PAF介导的WRP及兔多型核白细胞(PMNs)聚集的作用.结果 HSYA可浓度依赖地抑制1,2及4 nmol·L-1 3H]PAF与WRP受体的结合;HSYA抑制PAF介导的WRP及兔PMNs聚集,均具明显的量效关系,其IC50分别为0.99及0.70 mmol·L-1.结论 HSYA有PAF受体拮抗作用.

关 键 词:羟基红花黄色素A  血小板活化因子  受体结合试验  血小板聚集  多型核白细胞聚集
收稿时间:2002-02-25

ANTAGONISTIC EFFECT OF HYDROXYSAFFLOR YELLOW A ON THE PLATELET ACTIVATING FACTOR RECEPTOR
ZANG Bao-xia,JIN Ming,SI Nan,ZHANG Yan,WU Wei,PIAO Yong-zhe.ANTAGONISTIC EFFECT OF HYDROXYSAFFLOR YELLOW A ON THE PLATELET ACTIVATING FACTOR RECEPTOR[J].Acta Pharmaceutica Sinica,2002,37(9):696-699.
Authors:ZANG Bao-xia  JIN Ming  SI Nan  ZHANG Yan  WU Wei  PIAO Yong-zhe
Affiliation:Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.
Abstract:AIM: To observe the antagonistic effect of hydroxysafflor yellow A (HSYA) on the platelet activating factor (PAF). METHODS: Washed rabbit platelet (WRP) aggregation and rabbit polymorphonuclear leukocytes (PMNs) aggregation induced by PAF were observed by turbidimetric assay in vitro. The PAF receptor antagonistic effect of HSYA was investigated by radio ligand binding assay (RLBA). RESULTS: In RLBA the specific binding inhibition effect of HSYA was found to be concentration-dependent in three different 3H]PAF concentrations. In the experiments, WRP aggregation and rabbit PMNs aggregation induced by PAF (9.55 x 10(-10), 9.55 x 10(-6) mol.L-1) were both inhibited by HSYA in a concentration-dependent manner in vitro. The IC50 of HSYA to inhibit WRP and rabbit PMNs aggregation was 0.99 and 0.70 mmol.L-1, respectively. CONCLUSION: The PAF receptor binding can be antagonized by HSYA.
Keywords:hydroxysafflor yellow A  platelet activating factor  receptor binding assay  pla telet aggregation  polymorphonuclear leukocytes aggregation
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