| 川芎哚的结构改造及生物活性研究 |
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| 引用本文： | 唐刚华,姜国辉,王世真,吴淑琴,郑连芳.川芎哚的结构改造及生物活性研究[J].药学学报,1999,34(7):498-504. |
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| 作者姓名： | 唐刚华 姜国辉 王世真 吴淑琴 郑连芳 |
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| 作者单位： | 中国医学科学院、中国协和医科大学北京协和医院核医学科,北京10073 |
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| 基金项目： | 高等学校博士学科点专项科研基金,国家自然科学基金 |
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| 摘 要： | 目的:寻找新型的心血管药物。方法:根据推理药物设计原理,设计合成目标化合物,并研究其生物活性。结果:合成了16个川芎哚的类似物(I～XVI),其中8个化合物(I,I,V～VI,IX,XI和XV)是新化合物。结论:所合成的川芎哚类似物均有一定程度的抗血小板聚集作用,其中I～IV,VI,X,XI及XII有一定程度的抗血栓作用。
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| 关 键 词： | 川芎哚 结构改造 抗血小板聚集 抗血栓 |
| 收稿时间： | 1998-08-12 |
STRUCTURAL MODIFICATION AND BIOACTIVITY OF PERLOLYRINE |
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| Tang Ganghua,Jiang Guohui,Wang Shizhen,Wu Shuqin,Zheng Lianfang.STRUCTURAL MODIFICATION AND BIOACTIVITY OF PERLOLYRINE[J].Acta Pharmaceutica Sinica,1999,34(7):498-504. |
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| Authors: | Tang Ganghua Jiang Guohui Wang Shizhen Wu Shuqin Zheng Lianfang |
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| Abstract: | AIM: To search for compounds for the treatment of cardiovascular diseases. METHODS: According to rational drug design principle, a series of analogues of perlolyrine were prepared, and the antiplatelet aggregation activity and antithrombotic effects of these compounds were tested. RESULTS: Sixteen perlolyrine analogues were synthsized(I～XVI). Of them, 8 compounds(I,II,V～VII,IX,XI and XV) were first reported. CONCLUSION: All synthesized compounds showed antiplatelet aggregation activity to a certain degree. Of them, 8 compounds(I～IV,VII,X,XI and XIII) exhibited antithrombotic effects. |
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| Keywords: | perlolyrine structural modification antiplatelet aggregation antithrombotic effects |
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