| 奥替普拉在阻断细胞恶性转化时对某些基因表达的影响 |
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| 引用本文： | 柏华,罗贤懋,胡国刚,魏慧娟,李中骞.奥替普拉在阻断细胞恶性转化时对某些基因表达的影响[J].药学学报,1999,34(3):232-234. |
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| 作者姓名： | 柏华 罗贤懋 胡国刚 魏慧娟 李中骞 |
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| 作者单位： | 中国协和医科大学、中国医学科学院肿瘤研究所,北京,100021 |
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| 摘 要： | 奥替普拉（ｏｌｔｉｐｒａｚ）来源于十字花科（Ｃｒｕｃｉｆｅｒａｓｅ）蔬菜，全称５（２吡嗪基）４甲１，２２羟基３硫酮，文献报道它为一种防癌抑癌剂［１］。我们用致癌素香烟凝聚物（ｃｉｇａｒｅｔｅｓｍｏｋｉｎｇｃｏｎｄｅｎｓａｔｅＣＳＣ）诱发...
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| 关 键 词： | 奥替普拉 谷胱甘肽-S-转移酶-π ras基因 |
| 收稿时间： | 1998-03-12 |
| 修稿时间： | : 1998-03- |
EFFECT OF SOME GENES EXPRESSION IN INHIBITION OF CELLUAR MALIGNANT TRANSFORMATION BY OLTIPRAZ |
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| Bai Hua,Luo Xianmao,Hu Guogang,Wei Huijuan,Li Zhongqian.EFFECT OF SOME GENES EXPRESSION IN INHIBITION OF CELLUAR MALIGNANT TRANSFORMATION BY OLTIPRAZ[J].Acta Pharmaceutica Sinica,1999,34(3):232-234. |
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| Authors: | Bai Hua Luo Xianmao Hu Guogang Wei Huijuan Li Zhongqian |
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| Abstract: | AIM: To investigate the effect of some gene expression in inhibition of celluar malignant transformation by oltipraz. METHODS: Human fetal lung (HFL) treated with cigarette smoking condensate (CSC) and / or oltipraz was extracted for DNA and transfected into Rat-1 cell. C-Ha-ras gene mutation of Rat-1 and transformated Rat-1 cell were analyzed by PCR-RFLP. GST activity and GST-π were examined by colorimetric determination and ELISA. RESULTS: Oltipraz can decrease GST activity and GST-π protein content along with its inhibition of HFL carcinogenesis, but no obvious effect on mP53 gene expression. CONCLUSION: The effects of GST-π and C-Ha-ras gene may be involved in inhibition of cellular malignant transformation by oltipraz. |
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| Keywords: | GST-π ras gene oltipraz |
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