| 多肽合成中"困难序列"的缩合研究进展 |
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| 引用本文： | 韩香,王德心.多肽合成中"困难序列"的缩合研究进展[J].药学学报,2007,42(2):111-117. |
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| 作者姓名： | 韩香 王德心 |
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| 作者单位： | 中国医学科学院、中国协和医科大学,药物研究所,北京,100050 |
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| 摘 要： | 化学学科发展至今拥有极强的能力来获得高的合成效率，但是在多肽合成中“困难序列”的存在仍然成为成功缩合的巨大挑战。本文综述了影响多肽缩合效率的因素以及提高“困难序列”缩合效率的有效方法。所述方法均简便易行，适用于多肽的固相合成或液相合成。
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| 关 键 词： | 多肽合成 缩合效率 困难序列 β-构象 |
| 文章编号： | 0513-4870（2007）02-0111-07 |
| 收稿时间： | 2006-06-01 |
| 修稿时间： | 2006-06-01 |
Recent progress in the improvement of the coupling efficiency of "difficult sequences" in peptide synthesis |
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| HAN Xiang,WANG De-xin.Recent progress in the improvement of the coupling efficiency of "difficult sequences" in peptide synthesis[J].Acta Pharmaceutica Sinica,2007,42(2):111-117. |
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| Authors: | HAN Xiang WANG De-xin |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Even though chemistry is now in place that potentially allows high coupling efficiencies to be attained, successful coupling is usually a challenge when so-called "difficult sequences" is encountered in peptide synthesis. Some factors that affect the coupling efficiency have been discussed and related methods to overcome those obstacles have been introduced in present review. All suggestions proposed here are valuable and also feasible to improve the coupling completeness in both liquid-phase or solid-phase peptide synthesis. |
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| Keywords: | peptide synthesis coupling efficiency difficult sequences |
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