| 新疆藁本有效成分coniselin的全合成研究 |
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| 引用本文： | 丁平羽,于德泉.新疆藁本有效成分coniselin的全合成研究[J].药学学报,1995,30(10):796-800. |
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| 作者姓名： | 丁平羽 于德泉 |
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| 作者单位： | 中国医学科学院，中国协和医科大学药物研究所 |
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| 摘 要： | 新疆藁本有效成分ｃｏｎｉｓｅｌｉｎ的全合成研究丁平羽，于德泉（中国医学科学院，中国协和医科大学药物研究所北京１０００５０）新疆藁本（ＣｏｎｉｓｅｌｉｎｕｍｖａｇｉｎａｔｕｍＴｈｅｌｌ）是新疆地区常用中药藁本的代用品，应用广泛，主要功能是祛风散寒。本研...
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| 关 键 词： | 新疆藁本 4-亚甲二氧基-5-甲氧基苯乙酸-(3 4-亚甲二氧基-5-甲氧基)肉桂酯 选择性还原 |
| 收稿时间： | 1994-12-30 |
STUDIES ON TOTAL SYNTHESIS OF CONISTLIN AN ACTIVE PRINCIPLE ISOLATED FROM CONISELINUM VAGINATUM THELL |
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| PY Ding and DQ Yu.STUDIES ON TOTAL SYNTHESIS OF CONISTLIN AN ACTIVE PRINCIPLE ISOLATED FROM CONISELINUM VAGINATUM THELL[J].Acta Pharmaceutica Sinica,1995,30(10):796-800. |
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| Authors: | PY Ding and DQ Yu |
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| Abstract: | Three compounds(N1,N2 and
N3)had been isolated from Coniselinum vaginatum Thell and were shown
to have strong hepatoprotective activities.Coniselin(N4)is a new
naturalcompound isolated from the alcoholic extracts of C.vaginatum
Thell.To confirm its structure andprepare enough sample for
investigating its pharmacological activities , total synthesis of
this compoundwas carried out.3-Methoxy-4,5-dihydroxy-methyl benzoate
was used as starting material ,the targetmolecule was synthesized via
a reaction sequence of 9 steps in an overall yield of 16.3%.
Thiscompound was characterized by 1HNMR,IR,13CNMR and MS and was
found to have nohepatoprotective activity in preliminary
pharmacological tests. |
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| Keywords: | Coniselinum vaginatum Thell Coniselin Selective reduction |
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