| 苦参碱对细菌脂多糖诱导大鼠枯否细胞释放肿瘤坏死因子及白细胞介素-6的影响 |
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| 引用本文： | 林文,张俊平,胡振林,钱定华.苦参碱对细菌脂多糖诱导大鼠枯否细胞释放肿瘤坏死因子及白细胞介素-6的影响[J].药学学报,1997,32(2):93-96. |
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| 作者姓名： | 林文 张俊平 胡振林 钱定华 |
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| 作者单位： | 第二军医大学药学院中西药研究室,上海200433 |
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| 摘 要： | 目的是研究苦参碱对细菌脂多糖(lipopolysachrides,LPS)诱导经卡西霉素(calcimycin,Cal)预激活的大鼠枯否细胞分泌肿瘤坏死因子(tumor necrosis factor,TNF)、白细胞介素-6(interleukin-6,IL-6)的影响以及对小鼠体内产生TNF和IL-6的影响。结果,苦参碱125,250及500mg·L-1剂量依赖性抑制大鼠枯否细胞分泌TNF和IL-6;苦参碱50及100mg·kg-1降低小鼠体内TNF和IL-6的水平。提示苦参碱的抗炎作用可能与其抑制TNF及IL-6的产生有关。
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| 关 键 词： | 苦参碱 肿瘤坏死因子 白细胞介素-6 脂多糖 枯否细胞 蛋白激酶C |
| 收稿时间： | 1996-03-11 |
INHIBITORY EFFECT OF MATRINE ON LIPOPOLYSACCHRIDE INDUCED TUMOR NECROSIS FACTOR AND INTERLEUKIN-6 PRODUCTION FROM RAT KUPFFER CELLS |
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| W Lin,JP Zhang,ZL Hu and DH Qian.INHIBITORY EFFECT OF MATRINE ON LIPOPOLYSACCHRIDE INDUCED TUMOR NECROSIS FACTOR AND INTERLEUKIN-6 PRODUCTION FROM RAT KUPFFER CELLS[J].Acta Pharmaceutica Sinica,1997,32(2):93-96. |
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| Authors: | W Lin JP Zhang ZL Hu and DH Qian |
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| Affiliation: | Research Laboratory of Natural and Synthetic Drugs, College of Pharmacy, Second Military Medical University, Shanghai 200433. |
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| Abstract: | The effect of matrine on the lipopolysacchride (LPS)-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cell was investigated. Results showed that matrine 125, 250 and 500 mg.L-1 suppressed TNF and IL-6 production from Cal-primed Kupffer cells in the presence of lipopolysacchrides (LPS, 100 micrograms.L-1) in a concentration-dependent manner. Treatment with matrine 50 and 100 mg.kg-1 before LPS injection(3.5 mg.kg-1) markedly decreased mouse serum TNF and IL-6. The results suggest that matrine may have protective effect on LPS-induced liver injury. |
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| Keywords: | Tumor necrosis factor Interleukin-6 Kupffer cells Lipopolysacchrides Protein kinase C Matrine |
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