L-和DL-正丁基东莨菪碱对大鼠子宫作用的比较

用放射配基结合法测定L-正丁基东莨菪碱，DL-正丁基东莨菪碱与阿托品对大鼠子宫M 胆碱受体的亲和力。结果表明，L-与DL-正丁基东莨菪碱对大鼠子宫M胆碱受体的亲和力十分相近，但都比阿托品弱。比较L-正丁基东莨菪碱、DL-正丁基东莨菪碱和阿托品对离体大鼠子宫的影响及对抗乙酰胆碱所致的子宫收缩作用，表明两种正丁基东莨菪碱对离体大鼠子宫无影响，而能对抗乙酰胆碱所致的子宫收缩，且作用相近，但都比阿托品弱。说明生物效应与其受体亲和力的大小相关。

COMPARISON OF PHARMACOLOGICAL EFFECTS OF L-AND DL-N-BUTYL-SCOPOLAMINE IN RAT UTERUS

The affinities of L-n-butyl-scopolamine，DL-n-butyl-scopolamine and atropine for the M-cholinergic receptors of rat uterus were compared using radioligand binding assay．Results showed that the affinity of L-n-butyl-scopolamine for the M-receptors was similar to that of DL-n-butyl-scoplamine．but lower than that of atropine．In isolated rat uterus．L-and DL-n-butyl-scopolamine were found not to influence the automatic contraction but antagonize the contraction induced by acetylcholine with nearly the same PA₂，although the PA₂ of both compounds were still lower than that of atropine．Therefore，no difference between L-and DL-n-butyl-scopolamine in either biological activity or receptor affinity was observed．