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| 雷公藤榕碱的结构与分离 | |
| 引用本文： | 林绥,李援朝,樱井信子,曹剑虹,邓思珊,夏志林,谢狄霖.雷公藤榕碱的结构与分离[J].药学学报,2002,37(2):128-130. |
| 作者姓名： | 林绥 李援朝 樱井信子 曹剑虹 邓思珊 夏志林 谢狄霖 |
| 作者单位： | 1. 福建省医学科学研究所,福建,福州,350001 2. 中国科学院上海药物研究所,上海,200031 3. 日本星药科大学,东京ラ,142 |
| 基金项目： | 福建省科委重点项目 (99 7 16) |
| 摘 要： | 目的研究雷公藤(Tripterygium wilfordii Hook.f.)的化学成分。方法应用各种色谱技术进行分离纯化,用UV,IR,MS,HRMS,1HNMR,13CNMR(COM和OFR),1H-1H COSY,1H-13C COSY,2D-NOESY,1H-13C COLOC鉴定化合物的结构。结果分离并鉴定了2个生物碱:I为wilforgine,II为雷公藤榕碱(wilfordlongine)。结论化合物II为一种新的倍半萜生物碱。 |
| 关 键 词： | 雷公藤 倍半萜生物碱 wilforgine 雷公藤榕碱 |
| 收稿时间： | 2001-08-02 |
ISOLATION AND STRUCTURE OF WILFORDLONGING FROM TRIPTERYGIUM WILFORDII HOOK .F. |
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| CHEN Xi-jing,ZHU Jia-bi,WANG Guang-ji,ZHOU Ming-xia,XU Yue-ning.ISOLATION AND STRUCTURE OF WILFORDLONGING FROM TRIPTERYGIUM WILFORDII HOOK .F.[J].Acta Pharmaceutica Sinica,2002,37(2):128-130. | |
| Authors: | CHEN Xi-jing ZHU Jia-bi WANG Guang-ji ZHOU Ming-xia XU Yue-ning |
| Affiliation: | Fujian Institute of Medical Sciences, Fuzhou 350001, China. |
| Abstract: | AIM To study the chemical composition of Tripterygirm wilfordii Hook.f. METHODS Colunm chromatography was used to separate the chemical constituents. UV, IR, MS, HRMS, 1HNMR , 13 CNMR (COM and OFR), 1H 1H COSY, 1H 13 C COSY, NOESY and COLOC spectra were used to determine the structures of the isolated constituents. RESULTS Two sesquiterpene alkaloids were isolated and their structures were elucidated as wilforgine and wilfordlongine on the basis of spectral evidence. CONCLUSION Wilfordclonine is a new sesquiterpene alkaloid. |
| Keywords: | Tripterygium wilfordii sesquiterpene alkaloids wilforgine wilfordlongine |
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