| 白花丹参化学成分的研究 |
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| 引用本文： | 李志田,杨保津,马广恩.白花丹参化学成分的研究[J].药学学报,1991,26(3):209-213. |
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| 作者姓名： | 李志田 杨保津 马广恩 |
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| 作者单位： | 浙江医科大学药学系，中国科学院上海药物研究所，中国科学院上海药物研究所 杭州 310006 中国科学院上海药物研究所植化室 上海200031，上海 200031，上海 200031 |
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| 摘 要： | 从白花丹参(Salvia miltiorrhiza f.alba)中分离出14个二萜醌类化合物,其中2个为新化合物,由光谱分析推定为1,2,15,16-四氢丹参醌(Ⅰ)和丹参醛(Ⅱ);另一个化合物Ⅲ与R0-090680的结构相同。化合物Ⅰ和Ⅲ对淋巴白血病细胞P388均有较强的抑制作用。
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| 关 键 词： | 白花丹参 1 2 15 16-四氢丹参醌 丹参醛 白血病P388 |
| 收稿时间： | 1989-12-08 |
CHEMICAL STUDIES OF SALVIA MILTIORRHIZA F.LBA |
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| ZT Li,BJ Yang and GE Ma.CHEMICAL STUDIES OF SALVIA MILTIORRHIZA F.LBA[J].Acta Pharmaceutica Sinica,1991,26(3):209-213. |
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| Authors: | ZT Li BJ Yang and GE Ma |
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| Affiliation: | Department of Pharmacy, Zhejiang Medical University, Hangzhou. |
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| Abstract: | Fourteen constituents were isolated from the roots of Salvia miltiorrhiza f. alba. Two of them were new compounds and were named 1,2,15,16-tetrahydrotanshiquinone (I) and tanshinaldehyde (II). The others were identified as Ro-090680 (III), dihydroisotanshone I (IV), danshexinkun B (V), miltirone (VI), nortanshinone (VII), hydroxytanshinone II-A (VIII), tanshinone I (IX), dihydrotanshinone I (X), tanshinone II-A (XI), cryptotanshinone (XII), methylenetanshiquinone (XIII), methyltanshinonate (XIV), I and III showed inhibitory activity against P388 Leukemia cell in vitro. III was reported to be a potent inhibitor of rabbit platelet aggregation induced by collagen. |
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| Keywords: | Salvia miltiorrhiza f alba 1 2 15 16-tetrahydrotanshiq uinone Tanshinaldehyde P_(388) Leukemia |
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