| 卟啉树状大分子化合物的合成及其抗活性氧作用 |
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| 引用本文： | 崔文彬,周洁,陈磊,邓小斌,郭春.卟啉树状大分子化合物的合成及其抗活性氧作用[J].中国药物化学杂志,2007,17(1):23-28. |
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| 作者姓名： | 崔文彬 周洁 陈磊 邓小斌 郭春 |
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| 作者单位： | 1. 沈阳药科大学,制药工程学院,辽宁,沈阳,110016
2. 深圳市天和医药科技开发有限公司,广东,深圳,518057 |
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| 摘 要： | 目的研究金属卟啉树状大分子化合物的合成并考察其作为超氧化物歧化酶（SOD）和过氧化氢酶（CAT）双功能模拟酶的活性。方法通过收敛式合成法合成酸性表面二价铜卟啉树状大分子化合物。用核黄素一蛋氨酸光照法进行抗活性氧作用实验。结果与结论合成了5个酸性表面二价铜卟啉化合物。药理数据显示，树状大分子化合物体积的大小将会影响其抗活性氧能力。
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| 关 键 词： | 树状大分子 金属卟啉 抗活性氧 收敛式合成法 |
| 文章编号： | 1005-0108（2007）01-0023-06 |
| 收稿时间： | 2006-05-23 |
| 修稿时间： | 2006-05-23 |
Preparation of dendritic porphyrins and their potential application as antioxidants |
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| CUI Wen-bin,ZHOU Jie,CHEN Lei,DENG Xiao-bin,GUO Chun.Preparation of dendritic porphyrins and their potential application as antioxidants[J].Chinese Journal of Medicinal Chemistry,2007,17(1):23-28. |
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| Authors: | CUI Wen-bin ZHOU Jie CHEN Lei DENG Xiao-bin GUO Chun |
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| Affiliation: | 1. School of Pharmaceutical Engeneering, Shenyang Pharmaceutical University, Shenyang 110016, China ; 2. Shenzhen Tianhe Pharm. Ltd., Shenzhen 518057, China |
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| Abstract: | Aim To study the synthesis of metal dendritic porphyrins and their activities as dual functional mimics of superoxide dismutase(SOD) and catalase(CAT).Methods Convergent synthetic method was used to prepare dendritic porphyrins and the abilities of antioxidant were tested through several experiments.Results and conclusion Five target compounds were prepared and tested.The results showed that the size of the dendritic porphyins affects antioxidant action of the porphyrin. |
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| Keywords: | dendrimer metal porphyrin antioxidant convergent synthetic method |
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