| 布洛芬衍生物的合成及抗炎活性 |
| |
| 引用本文： | 赵一玫,夏丹,艾彩萍,项光亚.布洛芬衍生物的合成及抗炎活性[J].中国药物化学杂志,2005,15(6):360-362,366. |
| |
| 作者姓名： | 赵一玫 夏丹 艾彩萍 项光亚 |
| |
| 作者单位： | 1. 华中科技大学,同济药学院,湖北,武汉,430030
2. 红桃开集团股份有限公司,湖北,武汉,430070 |
| |
| 摘 要： | 以布洛芬为原料,通过酯化反应得到4种布洛芬衍生物,其结构经IR、1H-NMR、MS和元素分析确证.以布洛芬为阳性对照,采用小鼠耳肿胀法测试其抗炎作用,结果显示所有目标化合物均具有抗炎活性,其中化合物3和4的抗炎活性分别是布洛芬的2倍和3倍.
|
| 关 键 词： | 药物化学 化合物制备 化学合成 布洛芬衍生物 抗炎 |
| 文章编号： | 1005-0108（2005）06-0360-03 |
| 收稿时间： | 2005-07-20 |
| 修稿时间： | 2005-07-20 |
Synthesis and anti-inflammatory activities of ibuprofen derivatives |
| |
| ZHAO Yi-mei,XIA Dan,AI Cai-ping,XIANG Guang-ya.Synthesis and anti-inflammatory activities of ibuprofen derivatives[J].Chinese Journal of Medicinal Chemistry,2005,15(6):360-362,366. |
| |
| Authors: | ZHAO Yi-mei XIA Dan AI Cai-ping XIANG Guang-ya |
| |
| Abstract: | From ibuprofen, four compounds were obtained by esterification. Their structures were all confirmed by IR, ^1H-NMR, MS and elemental analysis, and their anti-inflammatory activities were also evaluated with the model xylene-induced ear edema in mice, the results show that all of the 4 compounds have antiinflammatory activities, and the anti-inflammatory activities of compounds 3 and 4 are two or three times than that of ibuprofen, respectively. |
| |
| Keywords: | medicinal chemistry compound preparation chemical synthesis ibuprofen derivatives anti-inflammatory |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
