靶向于流感病毒神经氨酸酶新位点的抑制剂研究进展

流感是由流感病毒引起的一种严重影响人类生命健康的传染性疾病。神经氨酸酶是流感病毒表面的一种重要糖蛋白,在病毒的复制周期中起着关键作用,是抗流感病毒合理药物设计的理想靶点。自2006年以来,结构生物学研究发现了神经氨酸酶新的配体结合位点,为新型神经氨酸酶抑制剂的设计提供了依据。本文综述了靶向于神经氨酸酶新结合位点的抑制剂的研究。

Recent progress in the research of neuraminidase inhibitors targeting novel binding sites

Influenza, which is caused by influenza virus, is a great threat to human health. Neuraminidase is an important surface glycoprotein of influenza virus and plays a critical role in the viral replicative cycle. Therefore,it is an attractive target for the rational design of anti-influenza drugs. Several novel ligand binding sites of viral neuraminidase have been identified since the year of 2006, which paved way for the design of novel neuraminidase inhibitors. Herein, the research progress of neuraminidase inhibitors targeting these novel binding sites were reviewed.