Mucoadhesive and floating chitosan-coated alginate beads for the controlled gastric release of amoxicillin |
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Authors: | Teerawat Sahasathian Nalena Praphairaksit Nongnuj Muangsin |
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Affiliation: | (1) Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Republic of Singapore;(2) Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 1 Pesek Road, Jurong Island, Singapore, 627833, Republic of Singapore |
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Abstract: | This work focused on the development of mucoadhesive and floating chitosan-coated alginate beads as a gastroretensive delivery
vehicle for amoxicillin, towards the effective eradication of Helicobacter pylori, a major causative agent of peptic ulcers. Alginate was used as the core bead core polymer and chitosan as the mucoadhesive
polymer coating. Amoxicillin-loaded alginate beads coated with 0.5% (w/v) chitosan (ALG/0.5%CHI) exhibited excellent floating
ability, high encapsulation efficiency, high drug loading capacity, and a strong in vitro mucoadhesion to the gastric mucosal layer. In vitro, amoxicillin was released faster in simulated gastric fluid (pH 1.2, HCl) than in simulated intestinal fluid (phosphate buffer,
pH 7.4). ALG/0.5%CHI could be prepared with a > 90% drug encapsulation efficiency and exhibited more than 90% muco-adhesiveness,
100% floating ability, and achieved sustained release of amoxicillin for over six hours in SGF. |
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