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Ginsenoside Rg5, a genuine dammarane glycoside from Korean red ginseng |
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| Authors: | Shin Il Kim Jeong Hill Park Jae-Ha Ryu Jong Dae Park You Hui Lee Jae-Hyun Park Tae-Hee Kim Jong Moon Kim Nam-In Baek |
| Affiliation: | 1. Korea Ginseng & Tobacco Research Institute Yuseong, Shinseong-Dong 302, Yuseong-Ku, P.O. Box 7, 305-345, Taejeon, Korea 2. College of Pharmacy, Seoul National University, 151-742, Seoul, Korea 3. Department of Pharmacy, Sookmyung Women's University, 140-742, Seoul, Korea |
| Abstract: | A genuine dammarane glycoside, named ginsenoside Rg5, has been isolated by repeated column chromatography and preparative HPLC from the MeOH extract of Korean red ginseng (Panax ginseng C.A. Meyer). The chemical structure of ginsenoside Rg5 was determined as 3-O-β-D-glucopyranosyl (1→2)-β-D-glucopyranosyl] dammar-20(22),24-diene-3β,12β-diol by spectral and chemical methods. The stereostructure of a double bond at C-20(22) of ginsenoside Rg5 was characterized as (E) from the chemical shift of C-21 in the13C-NMR and a NOESY experiment in the1H-NMR. |
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