新生儿缺氧缺血性脑病神经元特异性烯醇化酶的变化

目的研究新生儿缺血缺氧性脑病（HIE）神经元特异性烯醇化酶（NSE）的变化,探讨它们对HIE患儿病情进展、病情程度、预后判断的价值。方法符合新生儿HIE诊断标准的病例39例,分为轻度HIE组和中重度HIE组,选取同时期出生健康新生儿为对照组,采用酶联免疫法对新生儿不同时间的血清NSE浓度进行测定,并对结果进行统计学分析。结果新生儿血清NSE浓度与新生儿HIE相关,且与其严重程度正相关,组间差异具有显著性统计学意义（P〈0.05）。结论血清中NSE水平可作为判断新生儿HIE和脑损伤程度的可靠指标。

Changes of neuron specificenolase levels in neonates with hypoxic-ischemic encephalopathy

Objective To exam neuron specific enolase （NSE） levels in neonates with hypox ic-ischemic encephalopathy （HIE） in order to study their roles in assessing clinical progress, severity and prognosis in children with HIE. Methods A total of 39 neonates with HIE, including mild, moderate and severe group were enrolled. 25 normal neonates were used as the control group, and the differences among the groups before and after the treatment were analyzed. Results Compared with the controls,the levels of serum NSE were significantly higher in neonates with HIE. The more severe the clinical degree of HIE was the more significantly the levels of serum NSE increased （P0.05）. Conclusion Serum NSE levels may be useful in assessment of disease severity and neurlogical outcome in children with HIE.