Centralized preparation of hazardous drugs |
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Authors: | P Larrouturou J Huchet and M -C Taugourdeau |
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Affiliation: | (1) Department of Pharmacy, Saint-Joseph Hospital, 7 Rue Pierre Larousse, 75674 Paris Cedex, France |
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Abstract: | In 1987, the manager of the Saint-Joseph Hospital (Paris, France) requested a reorganization of cytotoxic drug preparation. Protection for staff who handle hazardous drugs was the main concern. The conclusions drawn from a first analysis emphasize the advantages of a centralized reconstitution unit against a decentralized system. Subsequently, a workload study and an economic study (investment, maintenance, supplies, staff costs, comparative balance sheet and a 5-year simulation) were carried out, but to choose between a laminar airflow in aseptic room and an isolator in a conventional room. The selected isolator is the first of the conception: the central half-suit uses as a server, and four sleeves located on one side allow two technicians to work in a sterile and closed area without sterile garments. |
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Keywords: | Antineoplastic agents Cost and cost analysis Drug compounding Equipment and supplies Isolator Laminar airflow hood |
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