羧基化PEG修饰的磁流体的制备和表征(英文)

制备和表征肿瘤热疗用羧基化PEG修饰的Fe₃O₄磁流体。化学共沉淀方法制备四氧化三铁磁性纳米颗粒,然后用羧基化PEG修饰;用邻二氮菲显色法测定磁流体中铁的含量;沉降方法考察了制备的磁流体的稳定性;通过X射线衍射、透射电子显微镜、红外和振动样品磁强计对制备的磁流体进行表征;测定了磁流体在交变磁场作用下的热效应。羧基化PEG修饰的磁流体稳定性明显优于未修饰的;红外图谱和X衍射图谱证明所制备的磁流体样品由Fe₃O₄组成;透射电镜照片显示磁性粒子分散良好;经X衍射数据计算得磁性粒子的粒径约为5 nm;羧基化PEG修饰磁流体的饱和磁化强度和剩余磁化强度分别为47.01和3.41 emu/g。矫顽力为6.7 Oe;磁流体的特征吸收率为63.0 W/gFe]。羧基化PEG修饰的Fe₃O₄磁流体有望用于肿瘤热疗。

Preparation and characterization of ferromagnetic fluids modified by carboxyl PEG

To prepare and characterize the ferromagnetic fluid of Fe₃O₄ modified by carboxyl PEG（FF/carboxyl PEG） for hyperthermia of tumor,the magnetic nanoparticles（NPs） of Fe₃O₄were prepared by chemical co-precipitation method,and then modified with carboxyl PEG.The iron content of FFs was determined by spectrophotometric method using o-phenanthroline. The stability of FF/carboxyl PEG was assessed by the sedimentation method.FF/carboxyl PEG was characterized by X-ray diffraction（XRD）,transmission electron microscopy（TEM）,infrared spectrometry（IR） and vibrating sample magnetometer （VSM）.Heating effect of FF/carboxyl PEG was measured in an alternating magnetic field in vitro.The stability of FF/carboxyl PEG was much better than that of unmodified ferromagnetic fluid.FF/carboxyl PEG was proved to be composed of Fe₃O₄ by both XRD and IR.TEM showed that the ferromagnetic particles were well-dispersed.The average particle size was calculated as 5 nm by XRD.The saturation magnetization and residual magnetization of FF/carboxyl PEG were 47.01 and 3.41 emu/g,respectively. The coercive force was 6.7 Oe.The specific absorption rate（SAR） of the FF/carboxyl PEG was 63.0 W/gFe].The FF/carboxyl PEG shows the promise for hyperthermia of tumor.