| Influence of Preparation Factors on the Sustained Release of Nifedipine from Eudragit RL/RS Microspheres |
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| 作者姓名： | 傅崇东 蒋雪涛 胡晋红 张万国 |
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| 作者单位： | 第二军医大学药学院药剂教研室，第二军医大学长海医院药剂科 |
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| 摘 要： | 用乳剂—溶剂挥发法制备硝苯地平的丙烯酸树脂缓释微球。微球中药物的释放速度随丙烯酸树脂ＥｕｄｒａｇｉｔＲＬ／ＲＳ比率的增加以及制备时搅拌速率的增加而增大，随内相聚合物浓度的增加及微球粒径的增加而减小，释药５０％所需时间与微球粒径呈良好线性。微球的释药速率也随药物含量的增加（从４．２％到１６．７％）而增大，并快于药物结晶的溶解速率，但药物含量达２６．６％时，微球释药速率明显下降并低于药物结晶的溶解速率。用差热分析和Ｘ射线衍射分析证明，药物含量为４．２，９．４和１６．７％的微球中药物完全是以非晶态分散的，而含药２６．６％的微球中有药物结晶存在。不同微球释药低于７０％时，释放方式均符合Ｈｉｇｕｃｈｉ时间平方根方程。
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| 关 键 词： | 缓释微球 硝苯地平 丙烯酸树脂 释放速率 |
Influence of Preparation Factors on the Sustained Release of Nifedipine from Eudragit RL/RS Microspheres |
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| Chong Dong Fu ,Xue Tao Jiang ,Jin Hong Hu and Wan Guo Zhang.Influence of Preparation Factors on the Sustained Release of Nifedipine from Eudragit RL/RS Microspheres[J].Journal of Chinese Pharmaceutical Sciences,1997(4). |
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| Authors: | Chong Dong Fu Xue Tao Jiang Jin Hong Hu and Wan Guo Zhang |
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| Affiliation: | Chong Dong Fu 1,Xue Tao Jiang 1,Jin Hong Hu 2 and Wan Guo Zhang 2 1. Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433, 2. Pharmaceutical Department,Changhai Hospital,Second Military Med |
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| Abstract: | |
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| Keywords: | Sustained release microspheres Nifedipine Eudragit RL/RS Release rate |
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