E-钙粘蛋白、表皮生长因子受体、基质金属蛋白酶9表达与鼻咽癌预后的关系

目的：检测并探讨鼻咽癌组织中E-钙粘蛋白（E-cadherin, E-cad）、表皮生长因子受体（Epidermal Growth Factor Receptor, EGFR）和基质金属蛋白酶9（matrix metalloproteinase-9, MMP-9）的表达与侵袭转移、预后的关系。方法选取62例鼻咽癌标本及45例癌旁组织标本，采用免疫组织化学染色方法（S-P法）检测鼻咽癌和癌旁组织中E-cad、EGFR、MMP-9的表达，并对所选病例进行随访。结果鼻咽癌组织中E-cad表达异常、EGFR及MMP-9的阳性表达率均高于癌旁组织，差异具有统计学意义（P＜0.05），且三者的表达率与临床分期、有无淋巴结转移有关（P＜0.05），与年龄、性别无关（P＞0.05）。结论检测鼻咽癌患者E-cad、EGFR、MMP-9的表达情况对判断其恶性程度及预后有重要意义。

Study on the Relationship between Expression of E-cad,EGFR and MMP-9 and Metastasission in nasopharyngeal carcinoma.

Objective To study clinical relationship between the expression of E-cadherin（E-cad）、epidermal growth factor receptor （EGFR）、matrix metalloproteinase-9（MMP9）and Prognosis of nasopharyngeal carcinoma. Methods Immuno-histochemical method（S-P） was used to detect the expression of the E-cad、EGFR、MMP-9 in 62 cases of nasopharyngeal carcinoma and 45 cases of Nasopharyngeal normal tissues next to nasopharyngeal carcinoma. Results The positive expression rates of EGFR、MMP-9 and the abnormal expression rates of E-cad in the nasopharyngeal carcinoma were higher than those in the para-carcinoma tissues（P 〈 0.05）. Significant differences were found between the expression of the E-cad、EGFR and MMP-9 in nasopharyngeal carcinoma and clinical stage、lymph node metastasis（P 〈 0.05）.There was no significant correlation between E-cad、EGFR or MMP-9 expression and gender or age（ P〉0.05）. Conclusion There was significantly important to detect the expression of the E-cad、EGFR and MMP-9, which could forecast the degree of malignancy and prognosis of nasopharyngeal carcinoma .