ICP-MS法测定注射用水中16种金属元素的含量

目的：建立电感耦合等离子体质谱法（ICP-MS）测定注射用水中镁、铝、铬、铜、锌、砷、镉、锡、钡、铅、钙、钾、硒、银、钠、汞等16种元素含量的方法。方法：采用ICP-MS法碰撞池技术（CCT）,最大程度的减少多原子干扰,通过在线加入锂、钪、锗、铟、铱、铋内标液的方法校正由于基体效应和信号漂移对测量所造成的影响,样品直接酸化测定注射用水中的16种金属元素的含量。结果：ICP-MS技术测定16种金属元素的检测限范围为0.009-0.165 ng·ml^-1;标准曲线线性关系良好（r≥0.999 0）;回收率均在80%-120%范围之内（n=6）。结论：上述方法简便、快速、准确,可用于注射用水中16种金属元素含量的测定,并以此降低注射用水中存在毒性较大金属元素含量超标的潜在风险,为注射用水更严格的质量控制提供参考。

Determination of 16 Metallic Elements in Water for Injection by ICP-MS

Objective： To establish the methods for the determination of Mg,Al,K,Ca,Cr,Cu,Zn,As,Se,Ag,Cd,Sn,Ba,Pb,Na and Hg in water for injection. Methods： The sixteen metallic elements in water for injection were determined by ICP-MS. The collision cell technology（ CCT） was used to minimize the multiple atomic interference,and the matrix effect and signal drift were compensated by using Li,Sc,Ge,In,Ir and Bi as the internal standards and the samples were directly acidified to detect the metallic elements.Results： The detection limit range of the 16 metallic elements were from 0. 009 to 0. 165 ng·ml^-1. The calibration curves showed good linearity（ r≥0. 999 0）. The recoveries were within the range of 80%-120%（ n = 6）. Conclusion： The method is simple,rapid and accurate. It can be used to determine the contents of metallic elements to reduce the potential exceeding limit risk of toxic metal elements in water for injection. The methods also can provide reference for the more strict quality evaluation of water for injection.