| p38抑制剂对辐射损伤小鼠中免疫细胞的作用 |
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| 引用本文： | 李德冠,王月英,王小春,张恒,吴红英,路璐,孟爱民.p38抑制剂对辐射损伤小鼠中免疫细胞的作用[J].天津医药,2011,39(10):933-935. |
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| 作者姓名： | 李德冠 王月英 王小春 张恒 吴红英 路璐 孟爱民 |
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| 作者单位： | 300192 天津,北京协和医学院,中国医学科学院放射医学研究所 |
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| 基金项目： | 国家自然科学基金资助项目(项目编号:81072237,30770645); 973计划(项目编号:2011CB964800) |
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| 摘 要： | 目的:探讨利用p38抑制剂SB203580(SB)抑制p38通路对6Gy受照小鼠免疫细胞辐射损伤的作用。方法:取雄性C57BL/6小鼠30只,随机分为对照组、照射组和SB组,每组10只。SB组和照射组小鼠接受以6Gy137Csγ射线的全身照射。SB组小鼠照射24h后腹腔注射SB(15mg/kg),每2d1次,共给药5次,其余2组小鼠腹腔注射对照溶液。小鼠受照10d后处死,取外周血计数,流式细胞仪检测CD4、CD8、B220表达,取骨髓细胞测定ROS水平。结果:照射组外周血白细胞(WBC)、CD8、B220细胞比例较对照组明显下降,骨髓ROS水平升高(P<0.01)。SB组外周血CD8比例较照射组上升,骨髓ROS水平下降(P<0.01)。结论:SB对小鼠6Gy照射后造血免疫损伤有一定的缓解作用,其机制可能与其降低照射后骨髓细胞ROS水平有关。
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| 关 键 词： | p38丝裂原活化蛋白激酶类 γ射线 辐射损伤 抗原 CD8 抗原 CD4 模型 动物 |
Effects of p38 Inhibitor on the Immune Cells in Irradiated Mice |
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| LI Deguan,WANG Yueying,WANG Xiaochun,ZHANG Heng,WU Hongying,LU Lu,MENG Aimin.Effects of p38 Inhibitor on the Immune Cells in Irradiated Mice[J].Tianjin Medical Journal,2011,39(10):933-935. |
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| Authors: | LI Deguan WANG Yueying WANG Xiaochun ZHANG Heng WU Hongying LU Lu MENG Aimin |
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| Affiliation: | LI Deguan,WANG Yueying,WANG Xiaochun,ZHANG Heng,WU Hongying,LU Lu,MENG Aimin Institute of Radiation Medicine,Chinese Academy of Medical Science and Peking Union Medical Collage,Tianjin300192,China |
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| Abstract: | Objective:To observe the effects of p38 inhibitor SB203580 (SB) on the immune cells in mice exposed to 6 Gy irradiation. Methods:Thirty C57BL/6 mice were randomly divided into control group, irradiated group and SB group (n=10 for each). Mice of control group received sham irradiation, and the rest accepted 6 Gy total body irradiation. Mice in SB group were intraperitoneally injected 15 mg/kg of SB every other day for 5 times after irradiation. Mice of other two groups were treated with reference solution. ... |
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| Keywords: | p38 mitogen-activated protein kinases gamma rays radiation injuries antigens CD8 antigens CD4 models animal |
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