| Abstract: | Five prenylated flavonoids, including one new natural product, were isolated from an ethanol extract of the leaves of Maclura tinctoria (L.) Gaud. The new compound has been characterized as 2',4',4,2'-tetrahydroxy-3'-3'-methylbut-3'-enyl]chalcone (1). The known compounds were identified as 2',4',4-trihydroxy-3'-3'-methylbut-3'-enyl]chalcone (isobavachalcone) (2), 4,2'-dihydroxy-2'-1-hydroxy-1-methylethyl]-2',3'-dihydrofurano4',5':3',4']chalcone (bakuchalcone) (3), 4,4',5'-trihydroxy-6',6'-dimethyldihydropyrano2',3':5',6']chalcone (bavachromanol) (4), and 5,7,3',4'-tetrahydroxy-6,8-diprenylisoflavone (6,8-diprenylorobol) (5). All the isolated compounds were evaluated against the AIDS-related opportunistic fungal pathogens, Candida albicans and Cryptococcus neoformans. Compound 2 was active against both yeasts. |
