| 卡托普利渗透泵型控释片的药代动力学 |
| |
| 引用本文： | 徐璐,李三鸣,刘婷,赵国斌.卡托普利渗透泵型控释片的药代动力学[J].沈阳药科大学学报,2004,21(3):165-167. |
| |
| 作者姓名： | 徐璐 李三鸣 刘婷 赵国斌 |
| |
| 作者单位： | 1. 沈阳药科大学药学院,辽宁,沈阳,110016
2. 吉林省药品检验所,吉林,长春,130062 |
| |
| 摘 要： | 目的研究卡托普利渗透泵型控释片在家犬体内的药代动力学。方法以卡托普利普通片为对照 ,应用HPLC法测定血药浓度。结果卡托普利渗透泵型控释片和普通片的tmax分别为 5 5h和 1 5h ,t1/ 2 分别为 6 73h和 3 5 2h ,ρmax分别为 85 5 1和 172 5 3μg·L-1。相对生物利用度为(119 2 0± 2 3 2 0 ) %。结论渗透泵控释片血药浓度平稳 ,可较长时间保持有效血药浓度
|
| 关 键 词： | 卡托普利 渗透泵控释片 高效液相色谱法 生物利用度 药代动力学 |
| 文章编号： | 1006-2858(2004)03-0165-03 |
| 修稿时间： | 2003年10月14 |
Studies on the pharmacokinetics of captopril osmotic pump controlled release tablets |
| |
| XU Lu ,LI San-ming ,LIU Ting ,ZHAO Guo-bin.Studies on the pharmacokinetics of captopril osmotic pump controlled release tablets[J].Journal of Shenyang Pharmaceutical University,2004,21(3):165-167. |
| |
| Authors: | XU Lu LI San-ming LIU Ting ZHAO Guo-bin |
| |
| Affiliation: | XU Lu 1,LI San-ming 1,LIU Ting 1,ZHAO Guo-bin 2 |
| |
| Abstract: | Objective To study pharmacokinetics of dogs in vivo of captopril osmotic pump controlled release tablets.Method With Captopril common tablets as the reference,blood drug concentration was determined by HPLC.Results Main pharmacokinetic parameters are followed:t max of captopril osmotic pump controlled release tablets and reference tablets are 5.5 h and 1.5 h,t 1/2 are 6.73 h和 3.52 h,ρ max are 855.1 and 1 725.3 μg·L -1.Relative bioavailability is (119.20±23.20)%.Conclusion Plasma drug concentration of captopril osmotic pump controlled release tablets is balanced and effective plasma drug concentration is kept in longer time. |
| |
| Keywords: | captopril osmotic pump controlled release tablets HPLC bioavailability pharmacokinetics |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
