| 芹菜素固体脂质纳米粒的制备 |
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| 引用本文： | 刘 任,胡海洋,陈大为,乔明曦,刘 丹,赵秀丽.芹菜素固体脂质纳米粒的制备[J].沈阳药科大学学报,2009,26(5):335-337. |
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| 作者姓名： | 刘 任 胡海洋 陈大为 乔明曦 刘 丹 赵秀丽 |
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| 作者单位： | 沈阳药科大学,药学院,辽宁,沈阳,110016
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| 摘 要： | 目的为芹菜素新型制剂的研究和开发提供实验基础。方法采用热熔超声法制备芹菜素固体脂质纳米粒;以包封率为指标,通过正交试验对处方进行优化。结果制备的纳米粒为类球形,包封率为63.11%,平均粒径为(135±18)nm,zeta电位为-18.90 mV,36 h体外累积释放95.74%。结论热熔超声法可用于制备芹菜素固体脂质纳米粒。
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| 关 键 词： | 芹菜素 固体脂质纳米粒 热熔超声法 理化性质 |
| 收稿时间： | 2008-5-21 |
Preparation of apigenin solid lipid nanoparticles |
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| LIU Ren,HU Hai-yang,CHEN Da-wei,QIAO Ming-xi,LIU Dan,ZHAO Xiu-li.Preparation of apigenin solid lipid nanoparticles[J].Journal of Shenyang Pharmaceutical University,2009,26(5):335-337. |
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| Authors: | LIU Ren HU Hai-yang CHEN Da-wei QIAO Ming-xi LIU Dan ZHAO Xiu-li |
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| Affiliation: | (School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China) |
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| Abstract: | Objective To prepare apigenin solid lipid nanoparticles, optimize the formulation and investigate characteristics of the particles. Methods The apigenin solid lipid nanoparticles were prepared by melt-emulsification-ultrasound method. With the entrapment efficiencies as references, the formulation was optimized by the orthogonal design. Results The results showed that the nanoparticles were sphere-like with the mean size of （135±18）nm , the zeta potential of -18.90 mV and the entrapment efficiencies was 63.11 %. During 36 h, the cumulative release was 95.74 %．Conclusion Using the melt-emulsification-ultrasound method, the preparation of apigenin solid lipid nanoparticles is highly feasible． |
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| Keywords: | apigenin solid lipid nanoparticle melt-emulsification-ultrasound method physico-chemical property |
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